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000019830 0247_ $$2DOI$$a10.1016/j.clineuro.2011.01.011
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000019830 084__ $$2WoS$$aClinical Neurology
000019830 084__ $$2WoS$$aSurgery
000019830 1001_ $$0P:(DE-HGF)0$$aAmeli, M.$$b0
000019830 245__ $$aArbitrary visuo-motor mapping during object manipulation in mild cognitive impairment and Alzheimer's disease: A pilot study
000019830 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2011
000019830 300__ $$a453 - 458
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000019830 440_0 $$024863$$aClinical Neurology and Neurosurgery$$v113$$y6
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000019830 520__ $$aEmpirical evidence for an essential role of the hippocampal system in arbitrary visuo-motor mapping suggests that acquisition and retrieval of arbitrary visuo-motor mapping might be impaired in mild cognitive impairment (MCI) and Alzheimer's disease (AD). The present pilot study investigated whether MCI of amnestic type or AD impact upon the capacity to scale grip force in a predictive manner to the mass of an object to be lifted based on learned associations between arbitrary colour cues and mass. Patients with MCI (n=8) and AD (n=8) grasped and lifted two different masses (400g and 600g) in random order using a precision grip between index finger and thumb. In a "no cue" experiment, a non-informative neutral visual stimulus was presented prior to each lift, thereby disallowing any prediction about which of the two masses was going to be lifted in the next trial. In a "cue" experiment an arbitrary colour cue provided advance information about which of the two masses to be lifted. In the "no cue" condition patients scaled their grip force according to the mass of the preceding lift. In the "cue" experiment neither patients with amnestic MCI nor those with AD were able to adjust their grip force based on visuo-motor mappings with arbitrary colour cues. These preliminary data suggest that the hippocampal system plays an essential role for arbitrary visuo-motor mapping in the grip-lift task.
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000019830 650_2 $$2MeSH$$aAged
000019830 650_2 $$2MeSH$$aAged, 80 and over
000019830 650_2 $$2MeSH$$aAlzheimer Disease: physiopathology
000019830 650_2 $$2MeSH$$aAmnesia: physiopathology
000019830 650_2 $$2MeSH$$aAmnesia: psychology
000019830 650_2 $$2MeSH$$aBrain Mapping: methods
000019830 650_2 $$2MeSH$$aCognition Disorders: physiopathology
000019830 650_2 $$2MeSH$$aColor
000019830 650_2 $$2MeSH$$aCues
000019830 650_2 $$2MeSH$$aData Interpretation, Statistical
000019830 650_2 $$2MeSH$$aFemale
000019830 650_2 $$2MeSH$$aHand Strength: physiology
000019830 650_2 $$2MeSH$$aHippocampus: physiopathology
000019830 650_2 $$2MeSH$$aHumans
000019830 650_2 $$2MeSH$$aLearning: physiology
000019830 650_2 $$2MeSH$$aMale
000019830 650_2 $$2MeSH$$aMiddle Aged
000019830 650_2 $$2MeSH$$aMovement: physiology
000019830 650_2 $$2MeSH$$aPilot Projects
000019830 650_2 $$2MeSH$$aPsychomotor Performance: physiology
000019830 650_2 $$2MeSH$$aWeight Perception: physiology
000019830 650_7 $$2WoSType$$aJ
000019830 65320 $$2Author$$aGrip force
000019830 65320 $$2Author$$aLift force
000019830 65320 $$2Author$$aConditional motor learning
000019830 65320 $$2Author$$aHippocampal system
000019830 7001_ $$0P:(DE-HGF)0$$aKemper, F.$$b1
000019830 7001_ $$0P:(DE-HGF)0$$aSarfel, A.S.$$b2
000019830 7001_ $$0P:(DE-HGF)0$$aKessler, J.$$b3
000019830 7001_ $$0P:(DE-Juel1)131720$$aFink, G.R.$$b4$$uFZJ
000019830 7001_ $$0P:(DE-HGF)0$$aNowak, D.A.$$b5
000019830 773__ $$0PERI:(DE-600)2004613-3$$a10.1016/j.clineuro.2011.01.011$$gVol. 113, p. 453 - 458$$p453 - 458$$q113<453 - 458$$tClinical neurology and neurosurgery$$v113$$x0303-8467$$y2011
000019830 8567_ $$uhttp://dx.doi.org/10.1016/j.clineuro.2011.01.011
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