TY  - JOUR
AU  - Ameli, M.
AU  - Kemper, F.
AU  - Sarfel, A.S.
AU  - Kessler, J.
AU  - Fink, G.R.
AU  - Nowak, D.A.
TI  - Arbitrary visuo-motor mapping during object manipulation in mild cognitive impairment and Alzheimer's disease: A pilot study
JO  - Clinical neurology and neurosurgery
VL  - 113
SN  - 0303-8467
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - PreJuSER-19830
SP  - 453 - 458
PY  - 2011
N1  - Record converted from VDB: 12.11.2012
AB  - Empirical evidence for an essential role of the hippocampal system in arbitrary visuo-motor mapping suggests that acquisition and retrieval of arbitrary visuo-motor mapping might be impaired in mild cognitive impairment (MCI) and Alzheimer's disease (AD). The present pilot study investigated whether MCI of amnestic type or AD impact upon the capacity to scale grip force in a predictive manner to the mass of an object to be lifted based on learned associations between arbitrary colour cues and mass. Patients with MCI (n=8) and AD (n=8) grasped and lifted two different masses (400g and 600g) in random order using a precision grip between index finger and thumb. In a "no cue" experiment, a non-informative neutral visual stimulus was presented prior to each lift, thereby disallowing any prediction about which of the two masses was going to be lifted in the next trial. In a "cue" experiment an arbitrary colour cue provided advance information about which of the two masses to be lifted. In the "no cue" condition patients scaled their grip force according to the mass of the preceding lift. In the "cue" experiment neither patients with amnestic MCI nor those with AD were able to adjust their grip force based on visuo-motor mappings with arbitrary colour cues. These preliminary data suggest that the hippocampal system plays an essential role for arbitrary visuo-motor mapping in the grip-lift task.
KW  - Aged
KW  - Aged, 80 and over
KW  - Alzheimer Disease: physiopathology
KW  - Amnesia: physiopathology
KW  - Amnesia: psychology
KW  - Brain Mapping: methods
KW  - Cognition Disorders: physiopathology
KW  - Color
KW  - Cues
KW  - Data Interpretation, Statistical
KW  - Female
KW  - Hand Strength: physiology
KW  - Hippocampus: physiopathology
KW  - Humans
KW  - Learning: physiology
KW  - Male
KW  - Middle Aged
KW  - Movement: physiology
KW  - Pilot Projects
KW  - Psychomotor Performance: physiology
KW  - Weight Perception: physiology
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:21353384
UR  - <Go to ISI:>//WOS:000292437100004
DO  - DOI:10.1016/j.clineuro.2011.01.011
UR  - https://juser.fz-juelich.de/record/19830
ER  -