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@ARTICLE{Ameli:19830,
      author       = {Ameli, M. and Kemper, F. and Sarfel, A.S. and Kessler, J.
                      and Fink, G.R. and Nowak, D.A.},
      title        = {{A}rbitrary visuo-motor mapping during object manipulation
                      in mild cognitive impairment and {A}lzheimer's disease: {A}
                      pilot study},
      journal      = {Clinical neurology and neurosurgery},
      volume       = {113},
      issn         = {0303-8467},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-19830},
      pages        = {453 - 458},
      year         = {2011},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Empirical evidence for an essential role of the hippocampal
                      system in arbitrary visuo-motor mapping suggests that
                      acquisition and retrieval of arbitrary visuo-motor mapping
                      might be impaired in mild cognitive impairment (MCI) and
                      Alzheimer's disease (AD). The present pilot study
                      investigated whether MCI of amnestic type or AD impact upon
                      the capacity to scale grip force in a predictive manner to
                      the mass of an object to be lifted based on learned
                      associations between arbitrary colour cues and mass.
                      Patients with MCI (n=8) and AD (n=8) grasped and lifted two
                      different masses (400g and 600g) in random order using a
                      precision grip between index finger and thumb. In a "no cue"
                      experiment, a non-informative neutral visual stimulus was
                      presented prior to each lift, thereby disallowing any
                      prediction about which of the two masses was going to be
                      lifted in the next trial. In a "cue" experiment an arbitrary
                      colour cue provided advance information about which of the
                      two masses to be lifted. In the "no cue" condition patients
                      scaled their grip force according to the mass of the
                      preceding lift. In the "cue" experiment neither patients
                      with amnestic MCI nor those with AD were able to adjust
                      their grip force based on visuo-motor mappings with
                      arbitrary colour cues. These preliminary data suggest that
                      the hippocampal system plays an essential role for arbitrary
                      visuo-motor mapping in the grip-lift task.},
      keywords     = {Aged / Aged, 80 and over / Alzheimer Disease:
                      physiopathology / Amnesia: physiopathology / Amnesia:
                      psychology / Brain Mapping: methods / Cognition Disorders:
                      physiopathology / Color / Cues / Data Interpretation,
                      Statistical / Female / Hand Strength: physiology /
                      Hippocampus: physiopathology / Humans / Learning: physiology
                      / Male / Middle Aged / Movement: physiology / Pilot Projects
                      / Psychomotor Performance: physiology / Weight Perception:
                      physiology / J (WoSType)},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89572 - (Dys-)function and Plasticity (POF2-89572)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89572},
      shelfmark    = {Clinical Neurology / Surgery},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21353384},
      UT           = {WOS:000292437100004},
      doi          = {10.1016/j.clineuro.2011.01.011},
      url          = {https://juser.fz-juelich.de/record/19830},
}