Home > Publications database > Arbitrary visuo-motor mapping during object manipulation in mild cognitive impairment and Alzheimer's disease: A pilot study > print

001     19830
005     20210129210734.0
024 7 _ |2 pmid
|a pmid:21353384
024 7 _ |2 DOI
|a 10.1016/j.clineuro.2011.01.011
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037 _ _ |a PreJuSER-19830
041 _ _ |a eng
082 _ _ |a 610
084 _ _ |2 WoS
|a Clinical Neurology
084 _ _ |2 WoS
|a Surgery
100 1 _ |a Ameli, M.
|b 0
|0 P:(DE-HGF)0
245 _ _ |a Arbitrary visuo-motor mapping during object manipulation in mild cognitive impairment and Alzheimer's disease: A pilot study
260 _ _ |a Amsterdam [u.a.]
|b Elsevier Science
|c 2011
300 _ _ |a 453 - 458
336 7 _ |a Journal Article
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336 7 _ |a article
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440 _ 0 |a Clinical Neurology and Neurosurgery
|0 24863
|y 6
|v 113
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a Empirical evidence for an essential role of the hippocampal system in arbitrary visuo-motor mapping suggests that acquisition and retrieval of arbitrary visuo-motor mapping might be impaired in mild cognitive impairment (MCI) and Alzheimer's disease (AD). The present pilot study investigated whether MCI of amnestic type or AD impact upon the capacity to scale grip force in a predictive manner to the mass of an object to be lifted based on learned associations between arbitrary colour cues and mass. Patients with MCI (n=8) and AD (n=8) grasped and lifted two different masses (400g and 600g) in random order using a precision grip between index finger and thumb. In a "no cue" experiment, a non-informative neutral visual stimulus was presented prior to each lift, thereby disallowing any prediction about which of the two masses was going to be lifted in the next trial. In a "cue" experiment an arbitrary colour cue provided advance information about which of the two masses to be lifted. In the "no cue" condition patients scaled their grip force according to the mass of the preceding lift. In the "cue" experiment neither patients with amnestic MCI nor those with AD were able to adjust their grip force based on visuo-motor mappings with arbitrary colour cues. These preliminary data suggest that the hippocampal system plays an essential role for arbitrary visuo-motor mapping in the grip-lift task.
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Aged
650 _ 2 |2 MeSH
|a Aged, 80 and over
650 _ 2 |2 MeSH
|a Alzheimer Disease: physiopathology
650 _ 2 |2 MeSH
|a Amnesia: physiopathology
650 _ 2 |2 MeSH
|a Amnesia: psychology
650 _ 2 |2 MeSH
|a Brain Mapping: methods
650 _ 2 |2 MeSH
|a Cognition Disorders: physiopathology
650 _ 2 |2 MeSH
|a Color
650 _ 2 |2 MeSH
|a Cues
650 _ 2 |2 MeSH
|a Data Interpretation, Statistical
650 _ 2 |2 MeSH
|a Female
650 _ 2 |2 MeSH
|a Hand Strength: physiology
650 _ 2 |2 MeSH
|a Hippocampus: physiopathology
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Learning: physiology
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Middle Aged
650 _ 2 |2 MeSH
|a Movement: physiology
650 _ 2 |2 MeSH
|a Pilot Projects
650 _ 2 |2 MeSH
|a Psychomotor Performance: physiology
650 _ 2 |2 MeSH
|a Weight Perception: physiology
650 _ 7 |a J
|2 WoSType
653 2 0 |2 Author
|a Grip force
653 2 0 |2 Author
|a Lift force
653 2 0 |2 Author
|a Conditional motor learning
653 2 0 |2 Author
|a Hippocampal system
700 1 _ |a Kemper, F.
|b 1
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700 1 _ |a Sarfel, A.S.
|b 2
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700 1 _ |a Kessler, J.
|b 3
|0 P:(DE-HGF)0
700 1 _ |a Fink, G.R.
|b 4
|u FZJ
|0 P:(DE-Juel1)131720
700 1 _ |a Nowak, D.A.
|b 5
|0 P:(DE-HGF)0
773 _ _ |a 10.1016/j.clineuro.2011.01.011
|g Vol. 113, p. 453 - 458
|p 453 - 458
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|t Clinical neurology and neurosurgery
|v 113
|y 2011
|x 0303-8467
856 7 _ |u http://dx.doi.org/10.1016/j.clineuro.2011.01.011
909 C O |o oai:juser.fz-juelich.de:19830
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