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000019969 084__ $$2WoS$$aBiochemical Research Methods
000019969 084__ $$2WoS$$aPhysics, Atomic, Molecular & Chemical
000019969 084__ $$2WoS$$aSpectroscopy
000019969 1001_ $$0P:(DE-Juel1)VDB101059$$aFeuerstein, S.$$b0$$uFZJ
000019969 245__ $$aiHADAMAC: a complementary tool for sequential resonance assignment of globular and highly disordered protein
000019969 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2012
000019969 300__ $$a329 - 334
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000019969 440_0 $$09881$$aJournal of Magnetic Resonance$$v214$$x1090-7807
000019969 500__ $$aWe thank I. Ayala (IBS Grenoble) for help with the production of the protein samples used for this study, and S. Hoffmann (FZ Julich) for stimulating discussion on the NS5A project. This work has been supported in part by grants from the European Commission (FP7-I3-BIO-NMR contract No. 261862, FP7-ITN-IDPbyNMR contract No. 264257, and FPR-IRG-2008 contract No. 231082), and financial support from ARC to M.J.P. and from CEA to S.F.
000019969 520__ $$aAn experiment, iHADAMAC, is presented that yields information on the amino-acid type of individual residues in a protein by editing the (1)H-(15)N correlations into seven different 2D spectra, each corresponding to a different class of amino-acid types. Amino-acid type discrimination is realized via a Hadamard encoding scheme based on four different spin manipulations as recently introduced in the context of the sequential HADAMAC experiment. Both sequential and intra-residue HADAMAC experiments yield highly complementary information that greatly facilitate resonance assignment of proteins with high frequency degeneracy, as demonstrated here for a 188-residue intrinsically disordered protein fragment of the hepatitis C virus protein NS5A.
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000019969 536__ $$0G:(EU-Grant)231082$$aONCOMIRNA-BIOGENESIS - Biogenesis of Oncogenic MicroRNAs : from the structure of the microRNA processing complexes to the inhibition of the maturation of human oncogenes (231082)$$c231082$$fFP7-PEOPLE-IRG-2008$$x3
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000019969 65320 $$2Author$$aNMR
000019969 65320 $$2Author$$aProtein
000019969 65320 $$2Author$$aIDP
000019969 65320 $$2Author$$aSequential resonance assignment
000019969 65320 $$2Author$$aHADAMAC
000019969 650_2 $$2MeSH$$aAlgorithms
000019969 650_2 $$2MeSH$$aMagnetic Resonance Spectroscopy: methods
000019969 650_2 $$2MeSH$$aProteins: chemistry
000019969 650_2 $$2MeSH$$aProteins: ultrastructure
000019969 650_2 $$2MeSH$$aSoftware
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000019969 7001_ $$0P:(DE-HGF)0$$aPlevin, M.J.$$b1
000019969 7001_ $$0P:(DE-Juel1)132029$$aWillbold, D.$$b2$$uFZJ
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