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@ARTICLE{Feuerstein:19969,
author = {Feuerstein, S. and Plevin, M.J. and Willbold, D. and
Brutscher, B.},
title = {i{HADAMAC}: a complementary tool for sequential resonance
assignment of globular and highly disordered protein},
journal = {Journal of magnetic resonance},
volume = {214},
issn = {1090-7807},
address = {Amsterdam [u.a.]},
publisher = {Elsevier},
reportid = {PreJuSER-19969},
pages = {329 - 334},
year = {2012},
note = {We thank I. Ayala (IBS Grenoble) for help with the
production of the protein samples used for this study, and
S. Hoffmann (FZ Julich) for stimulating discussion on the
NS5A project. This work has been supported in part by grants
from the European Commission (FP7-I3-BIO-NMR contract No.
261862, FP7-ITN-IDPbyNMR contract No. 264257, and
FPR-IRG-2008 contract No. 231082), and financial support
from ARC to M.J.P. and from CEA to S.F.},
abstract = {An experiment, iHADAMAC, is presented that yields
information on the amino-acid type of individual residues in
a protein by editing the (1)H-(15)N correlations into seven
different 2D spectra, each corresponding to a different
class of amino-acid types. Amino-acid type discrimination is
realized via a Hadamard encoding scheme based on four
different spin manipulations as recently introduced in the
context of the sequential HADAMAC experiment. Both
sequential and intra-residue HADAMAC experiments yield
highly complementary information that greatly facilitate
resonance assignment of proteins with high frequency
degeneracy, as demonstrated here for a 188-residue
intrinsically disordered protein fragment of the hepatitis C
virus protein NS5A.},
keywords = {Algorithms / Magnetic Resonance Spectroscopy: methods /
Proteins: chemistry / Proteins: ultrastructure / Software /
Proteins (NLM Chemicals) / J (WoSType)},
cin = {ICS-6},
ddc = {550},
cid = {I:(DE-Juel1)ICS-6-20110106},
pnm = {Funktion und Dysfunktion des Nervensystems / BioSoft:
Makromolekulare Systeme und biologische
Informationsverarbeitung / IDPBYNMR - High resolution tools
to understand the functional role of protein intrinsic
disorder (264257) / ONCOMIRNA-BIOGENESIS - Biogenesis of
Oncogenic MicroRNAs : from the structure of the microRNA
processing complexes to the inhibition of the maturation of
human oncogenes (231082)},
pid = {G:(DE-Juel1)FUEK409 / G:(DE-Juel1)FUEK505 /
G:(EU-Grant)264257 / G:(EU-Grant)231082},
shelfmark = {Biochemical Research Methods / Physics, Atomic, Molecular
$\&$ Chemical / Spectroscopy},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:22123230},
UT = {WOS:000299656400043},
doi = {10.1016/j.jmr.2011.10.019},
url = {https://juser.fz-juelich.de/record/19969},
}