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000020067 0247_ $$2DOI$$a10.1002/hbm.21175
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000020067 084__ $$2WoS$$aNeurosciences
000020067 084__ $$2WoS$$aNeuroimaging
000020067 084__ $$2WoS$$aRadiology, Nuclear Medicine & Medical Imaging
000020067 1001_ $$0P:(DE-HGF)0$$aWerner, C.J.$$b0
000020067 245__ $$aAltered motor network activation and functional connectivity in adult Tourette's syndrome
000020067 260__ $$aNew York, NY$$bWiley-Liss$$c2011
000020067 300__ $$a2014 - 2026
000020067 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000020067 3367_ $$2BibTeX$$aARTICLE
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000020067 440_0 $$02398$$aHuman Brain Mapping$$v32$$x1065-9471$$y11
000020067 500__ $$3POF3_Assignment on 2016-02-29
000020067 500__ $$aContract grant sponsor: Medical Faculty, RWTH Aachen University (Rheinisch-Westfalische Technische Hochschule), Aachen, Germany; Contract grant sponsor: German Ministry for Education and Research (BMBF) and Siemens.
000020067 520__ $$aTourette's syndrome (TS) is a developmental neuropsychiatric disorder characterized by motor and vocal tics as well as psychiatric comorbidities. Disturbances of the fronto-striatal-thalamic pathways responsible for motor control and impulse inhibition have been previously described in other studies. Although differences in motor performance are well recognized, imaging data elucidating the neuronal correlates are scarce. Here, we examined 19 adult TS patients (13 men, aged 22-52 years, mean = 34.3 years) and 18 age- and sex-matched controls (13 men, aged 24-57 years, mean = 37.6 years) in a functional magnetic resonance imaging study at 1.5 T. We corrected for possible confounds introduced by tics, motion, and brain-structural differences as well as age, sex, comorbidities, and medication. Patients and controls were asked to perform a sequential finger-tapping task using their right, left, and both hands, respectively. Task performance was monitored by simultaneous MR-compatible video recording. Although behavioral data obtained during scanning did not show significant differences across groups, we observed differential neuronal activation patterns depending on both handedness (dominant vs. nondominant) and tapping frequency in frontal, parietal, and subcortical areas. When controlling for open motor performance, a failure of deactivation in easier task conditions was found in the subgenual cingulate cortex in the TS patients. In addition, performance-related functional connectivity of lower- and higher-order motor networks differed between patients and controls. In summary, although open performance was comparable, patients showed different neuronal networks and connectivity patterns when performing increasingly demanding tasks, further illustrating the impact of the disease on the motor system.
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000020067 588__ $$aDataset connected to Web of Science, Pubmed
000020067 650_2 $$2MeSH$$aAdult
000020067 650_2 $$2MeSH$$aAging: physiology
000020067 650_2 $$2MeSH$$aCerebral Cortex: pathology
000020067 650_2 $$2MeSH$$aCognition: physiology
000020067 650_2 $$2MeSH$$aDiagnostic and Statistical Manual of Mental Disorders
000020067 650_2 $$2MeSH$$aFemale
000020067 650_2 $$2MeSH$$aHumans
000020067 650_2 $$2MeSH$$aImage Processing, Computer-Assisted
000020067 650_2 $$2MeSH$$aInternational Classification of Diseases
000020067 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000020067 650_2 $$2MeSH$$aMale
000020067 650_2 $$2MeSH$$aMiddle Aged
000020067 650_2 $$2MeSH$$aMotor Neurons: physiology
000020067 650_2 $$2MeSH$$aNerve Net: pathology
000020067 650_2 $$2MeSH$$aNeural Pathways: pathology
000020067 650_2 $$2MeSH$$aPrincipal Component Analysis
000020067 650_2 $$2MeSH$$aPsychomotor Performance: physiology
000020067 650_2 $$2MeSH$$aTourette Syndrome: pathology
000020067 650_2 $$2MeSH$$aTourette Syndrome: psychology
000020067 650_2 $$2MeSH$$aYoung Adult
000020067 650_7 $$2WoSType$$aJ
000020067 65320 $$2Author$$afMRI
000020067 65320 $$2Author$$amotor control
000020067 65320 $$2Author$$aindependent component analysis
000020067 65320 $$2Author$$asubgenual cingulate cortex
000020067 7001_ $$0P:(DE-Juel1)VDB18939$$aStöcker, T.$$b1$$uFZJ
000020067 7001_ $$0P:(DE-HGF)0$$aKellermann, T.$$b2
000020067 7001_ $$0P:(DE-HGF)0$$aBath, J.$$b3
000020067 7001_ $$0P:(DE-HGF)0$$aBeldoch, M.$$b4
000020067 7001_ $$0P:(DE-HGF)0$$aSchneider, F.$$b5
000020067 7001_ $$0P:(DE-Juel1)VDB93195$$aWegener, H.P.$$b6$$uFZJ
000020067 7001_ $$0P:(DE-Juel1)131794$$aShah, N.J.$$b7$$uFZJ
000020067 7001_ $$0P:(DE-Juel1)VDB53016$$aNeuner, I.$$b8$$uFZJ
000020067 773__ $$0PERI:(DE-600)1492703-2$$a10.1002/hbm.21175$$gVol. 32, p. 2014 - 2026$$p2014 - 2026$$q32<2014 - 2026$$tHuman brain mapping$$v32$$x1065-9471$$y2011
000020067 8567_ $$uhttp://dx.doi.org/10.1002/hbm.21175
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000020067 9141_ $$y2011
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000020067 9201_ $$0I:(DE-Juel1)ZEL-20090406$$gZEL$$kZEL$$lZentralinstitut für Elektronik$$x1
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