TY  - JOUR
AU  - Werner, C.J.
AU  - Stöcker, T.
AU  - Kellermann, T.
AU  - Bath, J.
AU  - Beldoch, M.
AU  - Schneider, F.
AU  - Wegener, H.P.
AU  - Shah, N.J.
AU  - Neuner, I.
TI  - Altered motor network activation and functional connectivity in adult Tourette's syndrome
JO  - Human brain mapping
VL  - 32
SN  - 1065-9471
CY  - New York, NY
PB  - Wiley-Liss
M1  - PreJuSER-20067
SP  - 2014 - 2026
PY  - 2011
N1  - Contract grant sponsor: Medical Faculty, RWTH Aachen University (Rheinisch-Westfalische Technische Hochschule), Aachen, Germany; Contract grant sponsor: German Ministry for Education and Research (BMBF) and Siemens.
AB  - Tourette's syndrome (TS) is a developmental neuropsychiatric disorder characterized by motor and vocal tics as well as psychiatric comorbidities. Disturbances of the fronto-striatal-thalamic pathways responsible for motor control and impulse inhibition have been previously described in other studies. Although differences in motor performance are well recognized, imaging data elucidating the neuronal correlates are scarce. Here, we examined 19 adult TS patients (13 men, aged 22-52 years, mean = 34.3 years) and 18 age- and sex-matched controls (13 men, aged 24-57 years, mean = 37.6 years) in a functional magnetic resonance imaging study at 1.5 T. We corrected for possible confounds introduced by tics, motion, and brain-structural differences as well as age, sex, comorbidities, and medication. Patients and controls were asked to perform a sequential finger-tapping task using their right, left, and both hands, respectively. Task performance was monitored by simultaneous MR-compatible video recording. Although behavioral data obtained during scanning did not show significant differences across groups, we observed differential neuronal activation patterns depending on both handedness (dominant vs. nondominant) and tapping frequency in frontal, parietal, and subcortical areas. When controlling for open motor performance, a failure of deactivation in easier task conditions was found in the subgenual cingulate cortex in the TS patients. In addition, performance-related functional connectivity of lower- and higher-order motor networks differed between patients and controls. In summary, although open performance was comparable, patients showed different neuronal networks and connectivity patterns when performing increasingly demanding tasks, further illustrating the impact of the disease on the motor system.
KW  - Adult
KW  - Aging: physiology
KW  - Cerebral Cortex: pathology
KW  - Cognition: physiology
KW  - Diagnostic and Statistical Manual of Mental Disorders
KW  - Female
KW  - Humans
KW  - Image Processing, Computer-Assisted
KW  - International Classification of Diseases
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Aged
KW  - Motor Neurons: physiology
KW  - Nerve Net: pathology
KW  - Neural Pathways: pathology
KW  - Principal Component Analysis
KW  - Psychomotor Performance: physiology
KW  - Tourette Syndrome: pathology
KW  - Tourette Syndrome: psychology
KW  - Young Adult
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:21259388
UR  - <Go to ISI:>//WOS:000296850700020
DO  - DOI:10.1002/hbm.21175
UR  - https://juser.fz-juelich.de/record/20067
ER  -