Home > Publications database > Altered motor network activation and functional connectivity in adult Tourette's syndrome > print

001     20067
005     20250129092426.0
024 7 _ |2 pmid
|a pmid:21259388
024 7 _ |2 DOI
|a 10.1002/hbm.21175
024 7 _ |2 WOS
|a WOS:000296850700020
037 _ _ |a PreJuSER-20067
041 _ _ |a eng
082 _ _ |a 610
084 _ _ |2 WoS
|a Neurosciences
084 _ _ |2 WoS
|a Neuroimaging
084 _ _ |2 WoS
|a Radiology, Nuclear Medicine & Medical Imaging
100 1 _ |a Werner, C.J.
|b 0
|0 P:(DE-HGF)0
245 _ _ |a Altered motor network activation and functional connectivity in adult Tourette's syndrome
260 _ _ |a New York, NY
|b Wiley-Liss
|c 2011
300 _ _ |a 2014 - 2026
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |a Human Brain Mapping
|x 1065-9471
|0 2398
|y 11
|v 32
500 _ _ |3 POF3_Assignment on 2016-02-29
500 _ _ |a Contract grant sponsor: Medical Faculty, RWTH Aachen University (Rheinisch-Westfalische Technische Hochschule), Aachen, Germany; Contract grant sponsor: German Ministry for Education and Research (BMBF) and Siemens.
520 _ _ |a Tourette's syndrome (TS) is a developmental neuropsychiatric disorder characterized by motor and vocal tics as well as psychiatric comorbidities. Disturbances of the fronto-striatal-thalamic pathways responsible for motor control and impulse inhibition have been previously described in other studies. Although differences in motor performance are well recognized, imaging data elucidating the neuronal correlates are scarce. Here, we examined 19 adult TS patients (13 men, aged 22-52 years, mean = 34.3 years) and 18 age- and sex-matched controls (13 men, aged 24-57 years, mean = 37.6 years) in a functional magnetic resonance imaging study at 1.5 T. We corrected for possible confounds introduced by tics, motion, and brain-structural differences as well as age, sex, comorbidities, and medication. Patients and controls were asked to perform a sequential finger-tapping task using their right, left, and both hands, respectively. Task performance was monitored by simultaneous MR-compatible video recording. Although behavioral data obtained during scanning did not show significant differences across groups, we observed differential neuronal activation patterns depending on both handedness (dominant vs. nondominant) and tapping frequency in frontal, parietal, and subcortical areas. When controlling for open motor performance, a failure of deactivation in easier task conditions was found in the subgenual cingulate cortex in the TS patients. In addition, performance-related functional connectivity of lower- and higher-order motor networks differed between patients and controls. In summary, although open performance was comparable, patients showed different neuronal networks and connectivity patterns when performing increasingly demanding tasks, further illustrating the impact of the disease on the motor system.
536 _ _ |a Neurowissenschaften
|c L01
|2 G:(DE-HGF)
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Adult
650 _ 2 |2 MeSH
|a Aging: physiology
650 _ 2 |2 MeSH
|a Cerebral Cortex: pathology
650 _ 2 |2 MeSH
|a Cognition: physiology
650 _ 2 |2 MeSH
|a Diagnostic and Statistical Manual of Mental Disorders
650 _ 2 |2 MeSH
|a Female
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Image Processing, Computer-Assisted
650 _ 2 |2 MeSH
|a International Classification of Diseases
650 _ 2 |2 MeSH
|a Magnetic Resonance Imaging
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Middle Aged
650 _ 2 |2 MeSH
|a Motor Neurons: physiology
650 _ 2 |2 MeSH
|a Nerve Net: pathology
650 _ 2 |2 MeSH
|a Neural Pathways: pathology
650 _ 2 |2 MeSH
|a Principal Component Analysis
650 _ 2 |2 MeSH
|a Psychomotor Performance: physiology
650 _ 2 |2 MeSH
|a Tourette Syndrome: pathology
650 _ 2 |2 MeSH
|a Tourette Syndrome: psychology
650 _ 2 |2 MeSH
|a Young Adult
650 _ 7 |a J
|2 WoSType
653 2 0 |2 Author
|a fMRI
653 2 0 |2 Author
|a motor control
653 2 0 |2 Author
|a independent component analysis
653 2 0 |2 Author
|a subgenual cingulate cortex
700 1 _ |a Stöcker, T.
|b 1
|u FZJ
|0 P:(DE-Juel1)VDB18939
700 1 _ |a Kellermann, T.
|b 2
|0 P:(DE-HGF)0
700 1 _ |a Bath, J.
|b 3
|0 P:(DE-HGF)0
700 1 _ |a Beldoch, M.
|b 4
|0 P:(DE-HGF)0
700 1 _ |a Schneider, F.
|b 5
|0 P:(DE-HGF)0
700 1 _ |a Wegener, H.P.
|b 6
|u FZJ
|0 P:(DE-Juel1)VDB93195
700 1 _ |a Shah, N.J.
|b 7
|u FZJ
|0 P:(DE-Juel1)131794
700 1 _ |a Neuner, I.
|b 8
|u FZJ
|0 P:(DE-Juel1)VDB53016
773 _ _ |a 10.1002/hbm.21175
|g Vol. 32, p. 2014 - 2026
|p 2014 - 2026
|q 32<2014 - 2026
|0 PERI:(DE-600)1492703-2
|t Human brain mapping
|v 32
|y 2011
|x 1065-9471
856 7 _ |u http://dx.doi.org/10.1002/hbm.21175
909 C O |o oai:juser.fz-juelich.de:20067
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|l Funktion und Dysfunktion des Nervensystems
|b Leben
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913 2 _ |a DE-HGF
|b Key Technologies
|l Decoding the Human Brain
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|v Addenda
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914 1 _ |y 2011
915 _ _ |0 StatID:(DE-HGF)0010
|a JCR/ISI refereed
920 1 _ |k INM-4
|l Physik der Medizinischen Bildgebung
|g INM
|0 I:(DE-Juel1)INM-4-20090406
|x 0
920 1 _ |k ZEL
|l Zentralinstitut für Elektronik
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