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@ARTICLE{Saha:200832,
      author       = {Saha, Debasish and Testard, Fabienne and Grillo, Isabelle
                      and Zouhiri, Fatima and Desmaele, Didier and Radulescu,
                      Aurel and Desert, Sylvain and Brulet, Annie and Couvreur,
                      Patrick and Spalla, Olivier},
      title        = {{T}he role of solvent swelling in the self-assembly of
                      squalene based nanomedicines},
      journal      = {Soft matter},
      volume       = {11},
      number       = {21},
      issn         = {1744-6848},
      address      = {London},
      publisher    = {Royal Soc. of Chemistry},
      reportid     = {FZJ-2015-03212},
      pages        = {4173-4179},
      year         = {2015},
      abstract     = {Squalene based nanoparticles obtained via nanoprecipitation
                      are promising candidates as efficient anti-cancer drugs. In
                      order to highlight their preparation process and to
                      facilitate further clinical translation, the present study
                      enlightens the paramount role of the solvent in the
                      formation of these nanomedicines. Three different
                      squalene-based nanoparticles, i.e. squalenic acid,
                      deoxycytidine squalene and gemcitabine squalene, have been
                      investigated before and after organic solvent evaporation.
                      Size and structural analysis by Small Angle Neutron
                      Scattering revealed that droplets' size was uniquely
                      controlled by the solvent composition (ethanol–water),
                      which evolved during their gradual formation. The particles
                      were preferably swollen by water and the swelling increased
                      when less ethanol was present. Either coalescence or
                      fragmentation was observed depending on the increase or
                      decrease of the ethanol content, supporting an equilibrium
                      control of the size. Moreover, a high water swelling was
                      observed for the three local organization of the
                      nanodroplets (hexagonal for gemcitabine squalene, cubic for
                      deoxycytidine and not structured for squalenic acid) and
                      could be the source of the previously reported efficiency of
                      related anti-cancer squalene based nanomedicines.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {530},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000354963700004},
      pubmed       = {pmid:25873336},
      doi          = {10.1039/C5SM00592B},
      url          = {https://juser.fz-juelich.de/record/200832},
}