TY  - JOUR
AU  - Muhle-Karbe, Paul S
AU  - Derrfuss, Jan
AU  - Lynn, Margaret T
AU  - Neubert, Franz X
AU  - Fox, Peter T
AU  - Brass, Marcel
AU  - Eickhoff, Simon
TI  - Co-Activation-Based Parcellation of the Lateral Prefrontal Cortex Delineates the Inferior Frontal Junction Area.
JO  - Cerebral cortex
VL  - 26
IS  - 5
SN  - 1460-2199
CY  - Oxford
PB  - Oxford Univ. Press
M1  - FZJ-2015-03292
SP  - 2225-2241
PY  - 2016
AB  - The inferior frontal junction (IFJ) area, a small region in the posterior lateral prefrontal cortex (LPFC), has received increasing interest in recent years due to its central involvement in the control of action, attention, and memory. Yet, both its function and anatomy remain controversial. Here, we employed a meta-analytic parcellation of the left LPFC to show that the IFJ can be isolated based on its specific functional connections. A seed region, oriented along the left inferior frontal sulcus (IFS), was subdivided via cluster analyses of voxel-wise whole-brain co-activation patterns. The ensuing clusters were characterized by their unique connections, the functional profiles of associated experiments, and an independent topic mapping approach. A cluster at the posterior end of the IFS matched previous descriptions of the IFJ in location and extent and could be distinguished from a more caudal cluster involved in motor control, a more ventral cluster involved in linguistic processing, and 3 more rostral clusters involved in other aspects of cognitive control. Overall, our findings highlight that the IFJ constitutes a core functional unit within the frontal lobe and delineate its borders. Implications for the IFJ's role in human cognition and the organizational principles of the frontal lobe are discussed.
LB  - PUB:(DE-HGF)16
C6  - pmid:25899707
UR  - <Go to ISI:>//WOS:000377469500032
DO  - DOI:10.1093/cercor/bhv073
UR  - https://juser.fz-juelich.de/record/200954
ER  -