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@ARTICLE{IbrahimVerbaas:200955,
      author       = {Ibrahim-Verbaas, C. A. and Bressler, J. and Debette, S. and
                      Schuur, M. and Smith, A. V. and Bis, J. C. and Davies, G.
                      and Trompet, S. and Smith, J. A. and Wolf, C. and Chibnik,
                      L. B. and Liu, Y. and Vitart, V. and Kirin, M. and Petrovic,
                      K. and Polasek, O. and Zgaga, L. and Fawns-Ritchie, C. and
                      Hoffmann, P. and Karjalainen, J. and Lahti, J. and
                      Llewellyn, D. J. and Schmidt, C. O. and Mather, K. A. and
                      Chouraki, V. and Sun, Q. and Resnick, S. M. and Rose, L. M.
                      and Oldmeadow, C. and Stewart, M. and Smith, B. H. and
                      Gudnason, V. and Yang, Q. and Mirza, S. S. and Jukema, J. W.
                      and deJager, P. L. and Harris, T. B. and Liewald, D. C. and
                      Amin, N. and Coker, L. H. and Stegle, O. and Lopez, O. L.
                      and Schmidt, R. and Teumer, A. and Ford, I. and Karbalai, N.
                      and Becker, J. T. and Jonsdottir, M. K. and Au, R. and
                      Fehrmann, R. S. N. and Herms, S. and Nalls, M. and Zhao, W.
                      and Turner, S. T. and Yaffe, K. and Lohman, K. and van
                      Swieten, J. C. and Kardia, S. L. R. and Knopman, D. S. and
                      Meeks, W. M. and Heiss, G. and Holliday, E. G. and
                      Schofield, P. W. and Tanaka, T. and Stott, D. J. and Wang,
                      J. and Ridker, P. and Gow, A. J. and Pattie, A. and Starr,
                      J. M. and Hocking, L. J. and Armstrong, N. J. and McLachlan,
                      S. and Shulman, J. M. and Pilling, L. C. and Eiriksdottir,
                      G. and Scott, R. J. and Kochan, N. A. and Palotie, A. and
                      Hsieh, Y-C and Eriksson, J. G. and Penman, A. and Gottesman,
                      R. F. and Oostra, B. A. and Yu, L. and DeStefano, A. L. and
                      Beiser, A. and Garcia, M. and Rotter, J. I. and Nöthen, M.
                      M. and Hofman, A. and Slagboom, P. E. and Westendorp, R. G.
                      J. and Buckley, B. M. and Wolf, P. A. and Uitterlinden, A.
                      G. and Psaty, B. M. and Grabe, H. J. and Bandinelli, S. and
                      Chasman, D. I. and Grodstein, F. and Räikkönen, K. and
                      Lambert, J-C and Porteous, D. J. and Price, J. F. and
                      Sachdev, P. S. and Ferrucci, L. and Attia, J. R. and Rudan,
                      I. and Hayward, C. and Wright, A. F. and Wilson, J. F. and
                      Cichon, S. and Franke, L. and Schmidt, H. and Ding, J. and
                      de Craen, A. J. M. and Fornage, M. and Bennett, D. A. and
                      Deary, I. J. and Ikram, M. A. and Launer, L. J. and
                      Fitzpatrick, A. L. and Seshadri, S. and van Duijn, C. M. and
                      Mosley, T. H.},
      collaboration = {Scotland, Generation},
      title        = {{GWAS} for executive function and processing speed suggests
                      involvement of the {CADM}2 gene},
      journal      = {Molecular psychiatry},
      volume       = {21},
      issn         = {1476-5578},
      address      = {London},
      publisher    = {Macmillan},
      reportid     = {FZJ-2015-03293},
      pages        = {189–197},
      year         = {2016},
      abstract     = {To identify common variants contributing to normal
                      variation in two specific domains of cognitive functioning,
                      we conducted a genome-wide association study (GWAS) of
                      executive functioning and information processing speed in
                      non-demented older adults from the CHARGE (Cohorts for Heart
                      and Aging Research in Genomic Epidemiology) consortium.
                      Neuropsychological testing was available for 5429-32 070
                      subjects of European ancestry aged 45 years or older, free
                      of dementia and clinical stroke at the time of cognitive
                      testing from 20 cohorts in the discovery phase. We analyzed
                      performance on the Trail Making Test parts A and B, the
                      Letter Digit Substitution Test (LDST), the Digit Symbol
                      Substitution Task (DSST), semantic and phonemic fluency
                      tests, and the Stroop Color and Word Test. Replication was
                      sought in 1311-21860 subjects from 20 independent cohorts. A
                      significant association was observed in the discovery
                      cohorts for the single-nucleotide polymorphism (SNP)
                      rs17518584 (discovery P-value=3.12 × 10(-8)) and in the
                      joint discovery and replication meta-analysis (P-value=3.28
                      × 10(-9) after adjustment for age, gender and education) in
                      an intron of the gene cell adhesion molecule 2 (CADM2) for
                      performance on the LDST/DSST. Rs17518584 is located about
                      170 kb upstream of the transcription start site of the
                      major transcript for the CADM2 gene, but is within an intron
                      of a variant transcript that includes an alternative first
                      exon. The variant is associated with expression of CADM2 in
                      the cingulate cortex (P-value=4 × 10(-4)). The protein
                      encoded by CADM2 is involved in glutamate signaling
                      (P-value=7.22 × 10(-15)), gamma-aminobutyric acid (GABA)
                      transport (P-value=1.36 × 10(-11)) and neuron cell-cell
                      adhesion (P-value=1.48 × 10(-13)). Our findings suggest
                      that genetic variation in the CADM2 gene is associated with
                      individual differences in information processing
                      speed.Molecular Psychiatry advance online publication, 14
                      April 2015; doi:10.1038/mp.2015.37.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25869804},
      UT           = {WOS:000370817800005},
      doi          = {10.1038/mp.2015.37},
      url          = {https://juser.fz-juelich.de/record/200955},
}