000200989 001__ 200989
000200989 005__ 20210129215601.0
000200989 0247_ $$2doi$$a10.1016/j.cub.2015.04.022
000200989 0247_ $$2WOS$$aWOS:000355556600020
000200989 0247_ $$2Handle$$a2128/13967
000200989 0247_ $$2altmetric$$aaltmetric:3976896
000200989 0247_ $$2pmid$$apmid:25959965
000200989 037__ $$aFZJ-2015-03308
000200989 041__ $$aEnglish
000200989 082__ $$a570
000200989 1001_ $$0P:(DE-HGF)0$$aDanielmeier, C.$$b0$$eCorresponding author
000200989 245__ $$aAcetylcholine mediates behavioral and neural post-error control
000200989 260__ $$aLondon$$bCurrent Biology Ltd.$$c2015
000200989 3367_ $$2DRIVER$$aarticle
000200989 3367_ $$2DataCite$$aOutput Types/Journal article
000200989 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1490015223_19583
000200989 3367_ $$2BibTeX$$aARTICLE
000200989 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000200989 3367_ $$00$$2EndNote$$aJournal Article
000200989 520__ $$aHumans often commit errors when they are distracted by irrelevant information and no longer focus on what is relevant to the task at hand. Adjustments following errors are essential for optimizing goal achievement. The posterior medial frontal cortex (pMFC), a key area for monitoring errors, has been shown to trigger such post-error adjustments by modulating activity in visual cortical areas. However, the mechanisms by which pMFC controls sensory cortices are unknown. We provide evidence for a mechanism based on pMFC-induced recruitment of cholinergic projections to task-relevant sensory areas. Using fMRI in healthy volunteers, we found that error-related pMFC activity predicted subsequent adjustments in task-relevant visual brain areas. In particular, following an error, activity increased in those visual cortical areas involved in processing task-relevant stimulus features, whereas activity decreased in areas representing irrelevant, distracting features. Following treatment with the muscarinic acetylcholine receptor antagonist biperiden, activity in visual areas was no longer under control of error-related pMFC activity. This was paralleled by abolished post-error behavioral adjustments under biperiden. Our results reveal a prominent role of acetylcholine in cognitive control that has not been recognized thus far. Regaining optimal performance after errors critically depends on top-down control of perception driven by the pMFC and mediated by acetylcholine. This may explain the lack of adaptivity in conditions with reduced availability of cortical acetylcholine, such as Alzheimer’s disease.
000200989 536__ $$0G:(DE-HGF)POF3-572$$a572 - (Dys-)function and Plasticity (POF3-572)$$cPOF3-572$$fPOF III$$x0
000200989 7001_ $$0P:(DE-HGF)0$$aAllen, E. A.$$b1
000200989 7001_ $$0P:(DE-HGF)0$$aJocham, G.$$b2
000200989 7001_ $$0P:(DE-Juel1)131736$$aOnur, Özgür$$b3
000200989 7001_ $$0P:(DE-HGF)0$$aEichele, T.$$b4
000200989 7001_ $$0P:(DE-HGF)0$$aUllsperger, M.$$b5
000200989 773__ $$0PERI:(DE-600)2019214-9$$a10.1016/j.cub.2015.04.022$$n11$$p1461-1468$$tCurrent biology$$v25$$x0960-9822$$y2015
000200989 8564_ $$uhttps://juser.fz-juelich.de/record/200989/files/1-s2.0-S0960982215004352-main-1.pdf$$yOpenAccess
000200989 8564_ $$uhttps://juser.fz-juelich.de/record/200989/files/1-s2.0-S0960982215004352-main-1.gif?subformat=icon$$xicon$$yOpenAccess
000200989 8564_ $$uhttps://juser.fz-juelich.de/record/200989/files/1-s2.0-S0960982215004352-main-1.jpg?subformat=icon-1440$$xicon-1440$$yOpenAccess
000200989 8564_ $$uhttps://juser.fz-juelich.de/record/200989/files/1-s2.0-S0960982215004352-main-1.jpg?subformat=icon-180$$xicon-180$$yOpenAccess
000200989 8564_ $$uhttps://juser.fz-juelich.de/record/200989/files/1-s2.0-S0960982215004352-main-1.jpg?subformat=icon-640$$xicon-640$$yOpenAccess
000200989 8564_ $$uhttps://juser.fz-juelich.de/record/200989/files/1-s2.0-S0960982215004352-main-1.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000200989 909CO $$ooai:juser.fz-juelich.de:200989$$pdnbdelivery$$pVDB$$pdriver$$popen_access$$popenaire
000200989 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131736$$aForschungszentrum Jülich GmbH$$b3$$kFZJ
000200989 9130_ $$0G:(DE-HGF)POF2-333$$1G:(DE-HGF)POF2-330$$2G:(DE-HGF)POF2-300$$aDE-HGF$$bGesundheit$$lFunktion und Dysfunktion des Nervensystems$$vPathophysiological Mechanisms of Neurological and Psychiatric Diseases$$x0
000200989 9131_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x0
000200989 9141_ $$y2015
000200989 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000200989 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000200989 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000200989 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000200989 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record
000200989 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCURR BIOL : 2015
000200989 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000200989 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000200989 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000200989 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000200989 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000200989 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bCURR BIOL : 2015
000200989 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000200989 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000200989 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000200989 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000200989 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000200989 920__ $$lyes
000200989 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x0
000200989 980__ $$ajournal
000200989 980__ $$aVDB
000200989 980__ $$aUNRESTRICTED
000200989 980__ $$aI:(DE-Juel1)INM-3-20090406
000200989 9801_ $$aFullTexts