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@ARTICLE{Holtbernd:200990,
      author       = {Holtbernd, F. and Ma, Y. and Peng, S. and Schwartz, F. and
                      Timmermann, L. and Kracht, L. and Fink, Gereon Rudolf and
                      Tang, C. C. and Eidelberg, D. and Eggers, C.},
      title        = {{D}opaminergic correlates of metabolic network activity in
                      {P}arkinson’s disease},
      journal      = {Human brain mapping},
      volume       = {36},
      number       = {9},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2015-03309},
      pages        = {3575 - 3585},
      year         = {2015},
      abstract     = {Parkinson's disease (PD) is associated with distinct
                      metabolic covariance patterns that relate to the motor and
                      cognitive manifestations of the disorder. It is not known,
                      however, how the expression of these patterns relates to
                      measurements of nigrostriatal dopaminergic activity from the
                      same individuals. To explore these associations, we studied
                      106 PD subjects who underwent cerebral PET with both
                      18F-fluorodeoxyglucose (FDG) and 18F-fluoro-L-dopa (FDOPA).
                      Expression values for the PD motor- and cognition-related
                      metabolic patterns (PDRP and PDCP, respectively) were
                      computed for each subject; these measures were correlated
                      with FDOPA uptake on a voxel-by-voxel basis. To explore the
                      relationship between dopaminergic function and local
                      metabolic activity, caudate and putamen FDOPA PET signal was
                      correlated voxel-wise with FDG uptake over the entire brain.
                      PDRP expression correlated with FDOPA uptake in caudate and
                      putamen (P < 0.001), while PDCP expression correlated
                      with uptake in the anterior striatum (P < 0.001). While
                      statistically significant, the correlations were only of
                      modest size, accounting for less than $20\%$ of the overall
                      variation in these measures. After controlling for PDCP
                      expression, PDRP correlations were significant only in the
                      posterior putamen. Of note, voxel-wise correlations between
                      caudate/putamen FDOPA uptake and whole-brain FDG uptake were
                      significant almost exclusively in PDRP regions. Overall, the
                      data indicate that PDRP and PDCP expression correlates
                      significantly with PET indices of presynaptic dopaminergic
                      functioning obtained in the same individuals. Even so, the
                      modest size of these correlations suggests that in PD
                      patients, individual differences in network activity cannot
                      be explained solely by nigrostriatal dopamine loss},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000360209000019},
      pubmed       = {pmid:26037537},
      doi          = {10.1002/hbm.22863},
      url          = {https://juser.fz-juelich.de/record/200990},
}