% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Volz:200992,
      author       = {Volz, L. J. and Eickhoff, Simon and Pool, Eva-Maria and
                      Fink, Gereon Rudolf and Grefkes, Christian},
      title        = {{D}ifferential {M}odulation of {M}otor {N}etwork
                      {C}onnectivity during {M}ovements of the {U}pper and {L}ower
                      {L}imbs},
      journal      = {NeuroImage},
      volume       = {119},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2015-03311},
      pages        = {44-53},
      year         = {2015},
      abstract     = {Voluntary movements depend on a well-regulated interplay
                      between the primary motor cortex (M1) and premotor areas.
                      While to date the neural underpinnings of hand movements are
                      relatively well understood, we only have rather limited
                      knowledge on the cortical control of lower-limb movements.
                      Given that our hands and feet have different roles for
                      activities of daily living, with hand movements being more
                      frequently used in a lateralized fashion, we hypothesized
                      that such behavioral differences also impact onto network
                      dynamics underlying upper and lower limb movements. We,
                      therefore, used functional magnetic resonance imaging (fMRI)
                      and dynamic causal modeling (DCM) to investigate differences
                      in effective connectivity underlying isolated movements of
                      the hands or feet in 16 healthy subjects. The connectivity
                      analyses revealed that both movements of the hand and feet
                      were accompanied by strong facilitatory coupling of the
                      respective contralateral M1 representations with premotor
                      areas of both hemispheres. However, excitatory influences
                      were significantly lower for movements of the feet compared
                      to hand movements. During hand movements, the M1hand
                      representation ipsilateral to the movement was strongly
                      inhibited by premotor regions and the contralateral M1
                      homologue. In contrast, interhemispheric inhibition was
                      absent between the M1foot representations during foot
                      movements. Furthermore, M1foot ipsilateral to the moving
                      foot exerted promoting influences onto contralateral M1foot.
                      In conclusion, the generally stronger and more lateralized
                      coupling pattern associated with hand movements suggests
                      distinct fine-tuning of cortical control to underlie
                      voluntary movements with the upper compared to the lower
                      limb.},
      cin          = {INM-3 / INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-1-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000361182400005},
      pubmed       = {pmid:26095089},
      doi          = {10.1016/j.neuroimage.2015.05.101},
      url          = {https://juser.fz-juelich.de/record/200992},
}