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@ARTICLE{GonzlezGaitano:200996,
      author       = {González-Gaitano, Gustavo and da Silva, Marcelo A. and
                      Radulescu, Aurel and Dreiss, Cécile A.},
      title        = {{S}elective {T}uning of the {S}elf-{A}ssembly and
                      {G}elation of a {H}ydrophilic {P}oloxamine by
                      {C}yclodextrins},
      journal      = {Langmuir},
      volume       = {31},
      number       = {20},
      issn         = {1520-5827},
      address      = {Washington, DC},
      publisher    = {ACS Publ.},
      reportid     = {FZJ-2015-03315},
      pages        = {5645 - 5655},
      year         = {2015},
      abstract     = {Complexes formed between cyclodextrins (CDs) and polymers -
                      pseudopolyrotaxanes (PPRs) - are the starting point of a
                      multitude of supramolecular structures, which are proposed
                      for a wide range of biomedical and technological
                      applications. In this work, we investigate the complexation
                      of a range of cyclodextrins with Tetronic T1307, a four-arm
                      block copolymer of poly(ethylene oxide)-poly(propylene
                      oxide)-poly(ethylene oxide) with a pH-responsive central
                      ethylene diamine spacer, and its impact on micellization and
                      the sol–gel transition. At low concentrations, small-angle
                      neutron scattering (SANS) combined with dynamic light
                      scattering (DLS) measurements show the presence of spherical
                      micelles with a highly hydrated shell and a dehydrated core.
                      Increasing the temperature leads to more compact micelles
                      and larger aggregation numbers, whereas acidic conditions
                      induce a shrinking of the micelles, with fewer unimers per
                      micelle and a more hydrated corona. At high concentrations,
                      T1307 undergoes a sol–gel transition, which is suppressed
                      at pH below the pKa,1 (4.6). SANS data analysis reveals that
                      the gels result from a random packing of the micelles, which
                      have an increasing aggregation number and increasingly
                      dehydrated shell and hydrated core with the temperature.
                      Native CDs (α, β, γ-CD) can complex T1307, resulting in
                      the precipitation of a PPR. Instead, modified CDs compete
                      with micellization to an extent that is critically dependent
                      on the nature of the substitution. 1H and ROESY NMR combined
                      with SANS demonstrate that dimethylated β-CD can thread
                      onto the polymer, preferentially binding to the PO units,
                      thus hindering self-aggregation by solubilizing the
                      hydrophobic block. The various CDs are able to modulate the
                      onset of gelation and the extent of the gel phase, and the
                      effect correlates with the ability of the CDs to disrupt the
                      micelles, with the exception of a sulfated sodium salt of
                      β-CD, which, while not affecting the CMT, is able to fully
                      suppress the gel phase},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / ICS-1},
      ddc          = {670},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)ICS-1-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000355382300012},
      pubmed       = {pmid:25938931},
      doi          = {10.1021/acs.langmuir.5b01081},
      url          = {https://juser.fz-juelich.de/record/200996},
}