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@ARTICLE{Hersch:201132,
      author       = {Hersch, N. and Wolters, B. and Dreissen, G. and Springer,
                      R. and Kirchgessner, N. and Merkel, R. and Hoffmann, B.},
      title        = {{T}he constant beat: cardiomyocytes adapt their forces by
                      equal contraction upon environmental stiffening},
      journal      = {Biology open},
      volume       = {2},
      number       = {3},
      issn         = {2046-6390},
      address      = {Cambridge},
      publisher    = {Company},
      reportid     = {FZJ-2015-03437},
      pages        = {351 - 361},
      year         = {2013},
      abstract     = {Cardiomyocytes are responsible for the permanent blood flow
                      by coordinated heart contractions. This vital function is
                      accomplished over a long period of time with almost the same
                      performance, although heart properties, as its elasticity,
                      change drastically upon aging or as a result of diseases
                      like myocardial infarction. In this paper we have analyzed
                      late rat embryonic heart muscle cells' morphology,
                      sarcomere/costamere formation and force generation patterns
                      on substrates of various elasticities ranging from ∼1 to
                      500 kPa, which covers physiological and pathological heart
                      stiffnesses. Furthermore, adhesion behaviour, as well as
                      single myofibril/sarcomere contraction patterns, was
                      characterized with high spatial resolution in the range of
                      physiological stiffnesses (15 kPa to 90 kPa). Here,
                      sarcomere units generate an almost stable contraction of
                      $∼4\%.$ On stiffened substrates the contraction amplitude
                      remains stable, which in turn leads to increased force
                      levels allowing cells to adapt almost instantaneously to
                      changing environmental stiffness. Furthermore, our data
                      strongly indicate specific adhesion to flat substrates via
                      both costameric and focal adhesions. The general appearance
                      of the contractile and adhesion apparatus remains almost
                      unaffected by substrate stiffness.},
      cin          = {ICS-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-7-20110106},
      pnm          = {453 - Physics of the Cell (POF2-453)},
      pid          = {G:(DE-HGF)POF2-453},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000209206000012},
      pubmed       = {pmid:23519595},
      doi          = {10.1242/bio.20133830},
      url          = {https://juser.fz-juelich.de/record/201132},
}