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FZJ-2015-03554

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Axons Predict Neuronal Connectivity Within and Between Cortical Columns and Serve as Primary Classifiers of Interneurons in a Cortical Column

Feldmeyer, D. (Corresponding Author)FZJ* ; Helmstaedter, M.

2010
Springer-Verlag Berlin
ISBN: 978-1-4419-1675-4

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Please use a persistent id in citations: doi:10.1007/978-1-4419-1676-1_8

Abstract: The axonal projections of nerve cells have been used to infer synaptic connectivity ever since the drawings of Ramon y Cajal more than a hundred years ago. Here we review the assumptions behind these studies and report how axonal projections of thalamic and cortical neurons can be used to anatomically define cortical columns as innervation volumes in rat barrel cortex. We then apply this analysis to cortical interneurons and illustrate that it is the axonal projections of interneurons which best permit their functional classification with reference to cortical columns. We conclude that the axons of cortical nerve cells should serve as their primary classifiers, because they best indicate their function in the neocortical neuronal network.

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Contributing Institute(s):

1. Molekulare Organisation des Gehirns (INM-2)

Research Program(s):

1. 331 - Signalling Pathways and Mechanisms in the Nervous System (POF2-331) (POF2-331)

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