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000201255 1001_ $$0P:(DE-HGF)0$$aCosta, Ana Sofia$$b0
000201255 245__ $$aEvidence of the Sensitivity of the MoCA Alternate Forms in Monitoring Cognitive Change in Early Alzheimer's Disease
000201255 260__ $$aBasel$$bKarger$$c2014
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000201255 520__ $$aBackground/Aims: There is an increasing interest in using the Montreal Cognitive Assessment (MoCA) test as a monitoring tool in Alzheimer's disease (AD) in both research and clinical settings. Our aim was to investigate the utility of alternate forms of the MoCA in detecting cognitive deterioration in a sample of early AD patients followed longitudinally in an outpatient memory clinic. Method: Twenty-five patients with early-stage AD (prodromal or mild dementia) were administered the original version and one of two previously validated alternate forms of the MoCA within an interval of about 1 year. The decline over time and the rate of change of the MoCA were compared to the total score of a standardized neuropsychological assessment battery (Consortium to Establish a Registry of Alzheimer's Disease; CERAD-Plus). Responsiveness to change was determined by calculating standard response means and the respective effect sizes. Results: Sixty percent of the sample showed a clinical decline on the clinical dementia rating (CDR) scale. There was significant deterioration in the MoCA and CERAD total scores. Conclusion: The results demonstrate that the MoCA is capable of detecting change over time and seems to be a valid tool with small to moderate sensitivity for monitoring cognitive change in early AD.
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000201255 7001_ $$0P:(DE-HGF)0$$aReich, Arno$$b1
000201255 7001_ $$0P:(DE-HGF)0$$aFimm, Bruno$$b2
000201255 7001_ $$0P:(DE-HGF)0$$aKetteler, Simon Thomas$$b3
000201255 7001_ $$0P:(DE-HGF)0$$aSchulz, Joerg Bernhard$$b4
000201255 7001_ $$0P:(DE-Juel1)162203$$aReetz, Kathrin$$b5$$eCorresponding Author
000201255 773__ $$0PERI:(DE-600)1482186-2$$a10.1159/000351864$$gVol. 37, no. 1-2, p. 95 - 103$$n1-2$$p95 - 103$$tDementia and geriatric cognitive disorders$$v37$$x1421-9824$$y2014
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