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@ARTICLE{Bongarzone:201266,
      author       = {Bongarzone, Salvatore and Tran, Hoang Ngoc Ai and Cavalli,
                      Andrea and Roberti, Marinella and Carloni, Paolo and
                      Legname, Giuseppe and Bolognesi, Maria Laura},
      title        = {{P}arallel {S}ynthesis, {E}valuation, and {P}reliminary
                      {S}tructure−{A}ctivity {R}elationship of
                      2,5-{D}iamino-1,4-benzoquinones as a {N}ovel {C}lass of
                      {B}ivalent {A}nti-{P}rion {C}ompound},
      journal      = {Journal of medicinal chemistry},
      volume       = {53},
      number       = {22},
      issn         = {1520-4804},
      address      = {Washington, DC},
      publisher    = {ACS},
      reportid     = {FZJ-2015-03571},
      pages        = {8197 - 8201},
      year         = {2010},
      abstract     = {A library of 11 entries, featuring a
                      2,5-diamino-1,4-benzoquinones nucleus as spacer connecting
                      two aromatic prion recognition motifs, was designed and
                      evaluated against prion infection. Notably,
                      6-chloro-1,2,3,4-tetrahydroacridine 10 showed an EC50 of
                      0.17 μM, which was lower than that displayed by reference
                      compound BiCappa. More importantly, 10 possessed the
                      capability to contrast prion fibril formation and oxidative
                      stress, together with a low cytotoxicity. This study further
                      corroborates the bivalent strategy as a viable approach to
                      the rational design of anti-prion chemical probes.},
      cin          = {GRS / IAS-5},
      ddc          = {540},
      cid          = {I:(DE-Juel1)GRS-20100316 / I:(DE-Juel1)IAS-5-20120330},
      pnm          = {899 - ohne Topic (POF2-899)},
      pid          = {G:(DE-HGF)POF2-899},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000284287200029},
      doi          = {10.1021/jm100882t},
      url          = {https://juser.fz-juelich.de/record/201266},
}