| 001 | 201266 | ||
| 005 | 20240625095111.0 | ||
| 024 | 7 | _ | |2 doi |a 10.1021/jm100882t |
| 024 | 7 | _ | |2 ISSN |a 0022-2623 |
| 024 | 7 | _ | |2 ISSN |a 0095-9065 |
| 024 | 7 | _ | |2 ISSN |a 1520-4804 |
| 024 | 7 | _ | |2 ISSN |a 1943-2992 |
| 024 | 7 | _ | |2 WOS |a WOS:000284287200029 |
| 037 | _ | _ | |a FZJ-2015-03571 |
| 082 | _ | _ | |a 540 |
| 100 | 1 | _ | |0 P:(DE-HGF)0 |a Bongarzone, Salvatore |b 0 |
| 245 | _ | _ | |a Parallel Synthesis, Evaluation, and Preliminary Structure−Activity Relationship of 2,5-Diamino-1,4-benzoquinones as a Novel Class of Bivalent Anti-Prion Compound |
| 260 | _ | _ | |a Washington, DC |b ACS |c 2010 |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1433834621_26784 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 520 | _ | _ | |a A library of 11 entries, featuring a 2,5-diamino-1,4-benzoquinones nucleus as spacer connecting two aromatic prion recognition motifs, was designed and evaluated against prion infection. Notably, 6-chloro-1,2,3,4-tetrahydroacridine 10 showed an EC50 of 0.17 μM, which was lower than that displayed by reference compound BiCappa. More importantly, 10 possessed the capability to contrast prion fibril formation and oxidative stress, together with a low cytotoxicity. This study further corroborates the bivalent strategy as a viable approach to the rational design of anti-prion chemical probes. |
| 536 | _ | _ | |0 G:(DE-HGF)POF2-899 |a 899 - ohne Topic (POF2-899) |c POF2-899 |x 0 |f POF I |
| 588 | _ | _ | |a Dataset connected to CrossRef, juser.fz-juelich.de |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Tran, Hoang Ngoc Ai |b 1 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Cavalli, Andrea |b 2 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Roberti, Marinella |b 3 |
| 700 | 1 | _ | |0 P:(DE-Juel1)145614 |a Carloni, Paolo |b 4 |u fzj |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Legname, Giuseppe |b 5 |e Corresponding Author |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Bolognesi, Maria Laura |b 6 |e Corresponding Author |
| 773 | _ | _ | |0 PERI:(DE-600)1491411-6 |a 10.1021/jm100882t |g Vol. 53, no. 22, p. 8197 - 8201 |n 22 |p 8197 - 8201 |t Journal of medicinal chemistry |v 53 |x 1520-4804 |y 2010 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/201266/files/jm100882t.pdf |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/201266/files/jm100882t.gif?subformat=icon |x icon |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/201266/files/jm100882t.jpg?subformat=icon-1440 |x icon-1440 |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/201266/files/jm100882t.jpg?subformat=icon-180 |x icon-180 |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/201266/files/jm100882t.jpg?subformat=icon-640 |x icon-640 |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/201266/files/jm100882t.pdf?subformat=pdfa |x pdfa |y Restricted |
| 909 | C | O | |o oai:juser.fz-juelich.de:201266 |p VDB |
| 910 | 1 | _ | |0 I:(DE-588b)5008462-8 |6 P:(DE-Juel1)145614 |a Forschungszentrum Jülich GmbH |b 4 |k FZJ |
| 913 | 2 | _ | |0 G:(DE-HGF)POF3-899 |1 G:(DE-HGF)POF3-890 |2 G:(DE-HGF)POF3-800 |a DE-HGF |b Forschungsbereich Materie |l Forschungsbereich Materie |v ohne Topic |x 0 |
| 913 | 1 | _ | |0 G:(DE-HGF)POF2-899 |1 G:(DE-HGF)POF2-890 |2 G:(DE-HGF)POF2-800 |a DE-HGF |b Programmungebundene Forschung |l ohne Programm |v ohne Topic |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF2 |
| 915 | _ | _ | |0 StatID:(DE-HGF)0100 |2 StatID |a JCR |
| 915 | _ | _ | |0 StatID:(DE-HGF)0110 |2 StatID |a WoS |b Science Citation Index |
| 915 | _ | _ | |0 StatID:(DE-HGF)0111 |2 StatID |a WoS |b Science Citation Index Expanded |
| 915 | _ | _ | |0 StatID:(DE-HGF)0150 |2 StatID |a DBCoverage |b Web of Science Core Collection |
| 915 | _ | _ | |0 StatID:(DE-HGF)0199 |2 StatID |a DBCoverage |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |0 StatID:(DE-HGF)0200 |2 StatID |a DBCoverage |b SCOPUS |
| 915 | _ | _ | |0 StatID:(DE-HGF)0300 |2 StatID |a DBCoverage |b Medline |
| 915 | _ | _ | |0 StatID:(DE-HGF)0310 |2 StatID |a DBCoverage |b NCBI Molecular Biology Database |
| 915 | _ | _ | |0 StatID:(DE-HGF)1030 |2 StatID |a DBCoverage |b Current Contents - Life Sciences |
| 915 | _ | _ | |0 StatID:(DE-HGF)1050 |2 StatID |a DBCoverage |b BIOSIS Previews |
| 915 | _ | _ | |0 StatID:(DE-HGF)9905 |2 StatID |a IF >= 5 |
| 920 | _ | _ | |l yes |
| 920 | 1 | _ | |0 I:(DE-Juel1)GRS-20100316 |k GRS |l GRS |x 0 |
| 920 | 1 | _ | |0 I:(DE-Juel1)IAS-5-20120330 |k IAS-5 |l Computational Biomedicine |x 1 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-Juel1)GRS-20100316 |
| 980 | _ | _ | |a I:(DE-Juel1)IAS-5-20120330 |
| 980 | _ | _ | |a UNRESTRICTED |
| 981 | _ | _ | |a I:(DE-Juel1)INM-9-20140121 |
| 981 | _ | _ | |a I:(DE-Juel1)IAS-5-20120330 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|
guest ::