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000201300 1001_ $$0P:(DE-HGF)0$$aChiriano, Gianpaolo$$b0
000201300 245__ $$aA small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation
000201300 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2012
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000201300 520__ $$aIn this work, we report a rational structure-based approach aimed at the discovery of new 2-aminoimidazoles as β-secretase inhibitors. Taking advantage of a microwave-assisted synthetic protocol, a small library of derivatives was obtained and biologically evaluated. Two compounds showed promising activities in both enzymatic and cellular assays. Moreover, one of them exhibited the capability to cross the blood–brain barrier as assessed by the parallel artificial membrane permeability assay.
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000201300 7001_ $$0P:(DE-HGF)0$$aDe Simone, Angela$$b1
000201300 7001_ $$0P:(DE-HGF)0$$aMancini, Francesca$$b2
000201300 7001_ $$0P:(DE-HGF)0$$aPerez, Daniel I.$$b3
000201300 7001_ $$0P:(DE-HGF)0$$aCavalli, Andrea$$b4
000201300 7001_ $$0P:(DE-HGF)0$$aBolognesi, Maria Laura$$b5
000201300 7001_ $$0P:(DE-HGF)0$$aLegname, Giuseppe$$b6
000201300 7001_ $$0P:(DE-HGF)0$$aMartinez, Ana$$b7
000201300 7001_ $$0P:(DE-HGF)0$$aAndrisano, Vincenza$$b8
000201300 7001_ $$0P:(DE-Juel1)145614$$aCarloni, Paolo$$b9$$ufzj
000201300 7001_ $$0P:(DE-HGF)0$$aRoberti, Marinella$$b10$$eCorresponding Author
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