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@ARTICLE{Chiriano:201300,
      author       = {Chiriano, Gianpaolo and De Simone, Angela and Mancini,
                      Francesca and Perez, Daniel I. and Cavalli, Andrea and
                      Bolognesi, Maria Laura and Legname, Giuseppe and Martinez,
                      Ana and Andrisano, Vincenza and Carloni, Paolo and Roberti,
                      Marinella},
      title        = {{A} small chemical library of 2-aminoimidazole derivatives
                      as {BACE}-1 inhibitors: {S}tructure-based design, synthesis,
                      and biological evaluation},
      journal      = {European journal of medicinal chemistry},
      volume       = {48},
      issn         = {0223-5234},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2015-03605},
      pages        = {206 - 213},
      year         = {2012},
      abstract     = {In this work, we report a rational structure-based approach
                      aimed at the discovery of new 2-aminoimidazoles as
                      β-secretase inhibitors. Taking advantage of a
                      microwave-assisted synthetic protocol, a small library of
                      derivatives was obtained and biologically evaluated. Two
                      compounds showed promising activities in both enzymatic and
                      cellular assays. Moreover, one of them exhibited the
                      capability to cross the blood–brain barrier as assessed by
                      the parallel artificial membrane permeability assay.},
      cin          = {GRS / IAS-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)GRS-20100316 / I:(DE-Juel1)IAS-5-20120330},
      pnm          = {899 - ohne Topic (POF2-899)},
      pid          = {G:(DE-HGF)POF2-899},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000300484900022},
      doi          = {10.1016/j.ejmech.2011.12.016},
      url          = {https://juser.fz-juelich.de/record/201300},
}