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| 001 | 201300 | ||
| 005 | 20240625095113.0 | ||
| 024 | 7 | _ | |2 doi |a 10.1016/j.ejmech.2011.12.016 |
| 024 | 7 | _ | |2 ISSN |a 0223-5234 |
| 024 | 7 | _ | |2 ISSN |a 1768-3254 |
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| 037 | _ | _ | |a FZJ-2015-03605 |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |0 P:(DE-HGF)0 |a Chiriano, Gianpaolo |b 0 |
| 245 | _ | _ | |a A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation |
| 260 | _ | _ | |a Amsterdam [u.a.] |b Elsevier Science |c 2012 |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1434006600_12148 |2 PUB:(DE-HGF) |
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| 520 | _ | _ | |a In this work, we report a rational structure-based approach aimed at the discovery of new 2-aminoimidazoles as β-secretase inhibitors. Taking advantage of a microwave-assisted synthetic protocol, a small library of derivatives was obtained and biologically evaluated. Two compounds showed promising activities in both enzymatic and cellular assays. Moreover, one of them exhibited the capability to cross the blood–brain barrier as assessed by the parallel artificial membrane permeability assay. |
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| 700 | 1 | _ | |0 P:(DE-HGF)0 |a De Simone, Angela |b 1 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Mancini, Francesca |b 2 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Perez, Daniel I. |b 3 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Cavalli, Andrea |b 4 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Bolognesi, Maria Laura |b 5 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Legname, Giuseppe |b 6 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Martinez, Ana |b 7 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Andrisano, Vincenza |b 8 |
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| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Roberti, Marinella |b 10 |e Corresponding Author |
| 773 | _ | _ | |0 PERI:(DE-600)2005170-0 |a 10.1016/j.ejmech.2011.12.016 |g Vol. 48, p. 206 - 213 |p 206 - 213 |t European journal of medicinal chemistry |v 48 |x 0223-5234 |y 2012 |
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