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000201303 041__ $$aEnglish
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000201303 1001_ $$0P:(DE-HGF)0$$aSandal, Massimo$$b0
000201303 245__ $$aStructure/Function Relationships of Phospholipases C Beta
000201303 260__ $$aHilversum$$bBentham Science Publ.$$c2013
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000201303 520__ $$aPhospholipases C beta (PLC-βs) are essential components of the signal transduction of metazoans. They catalyze the production of the second messengers inositol-1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) from the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PIP2). These enzymes are activated by G-protein-coupled receptors (GPCRs) through the interaction with the alpha subunit of heterotrimeric G-proteins belonging to the Gq family (Gαq), the Gβγ subunits released by the inhibitory G-protein (Gi) and Ca2+ ions. Here we review current structural insights on these important proteins, with a particular focus on the most structurally characterized isoform (PLC-β3) and the activation mechanism operated by Gαq. We propose, following the lead of recent studies, that a tight combination of experiments and molecular simulations are instrumental in further enlightening the structure/function understanding of PLC-βs. - See more at: http://www.eurekaselect.com/116059/article#sthash.cojH1BB1.dpuf
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000201303 7001_ $$0P:(DE-HGF)0$$aPaltrinieri, Daniele$$b1
000201303 7001_ $$0P:(DE-Juel1)145614$$aCarloni, Paolo$$b2$$ufzj
000201303 7001_ $$0P:(DE-HGF)0$$aMusiani, Francesco$$b3$$eCorresponding Author
000201303 7001_ $$0P:(DE-HGF)0$$aGiorgetti, Alejandro$$b4$$eCorresponding Author
000201303 773__ $$0PERI:(DE-600)2044612-3$$a10.2174/13892037113146660085$$gVol. 14, no. 8, p. 650 - 657$$n8$$p650 - 657$$tCurrent protein & peptide science$$v14$$x1389-2037$$y2013
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