% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Sandal:201303,
      author       = {Sandal, Massimo and Paltrinieri, Daniele and Carloni, Paolo
                      and Musiani, Francesco and Giorgetti, Alejandro},
      title        = {{S}tructure/{F}unction {R}elationships of {P}hospholipases
                      {C} {B}eta},
      journal      = {Current protein $\&$ peptide science},
      volume       = {14},
      number       = {8},
      issn         = {1389-2037},
      address      = {Hilversum},
      publisher    = {Bentham Science Publ.},
      reportid     = {FZJ-2015-03608},
      pages        = {650 - 657},
      year         = {2013},
      abstract     = {Phospholipases C beta (PLC-βs) are essential components of
                      the signal transduction of metazoans. They catalyze the
                      production of the second messengers
                      inositol-1,4,5-trisphosphate (IP3) and diacylglycerol (DAG)
                      from the hydrolysis of phosphatidylinositol-4,5-bisphosphate
                      (PIP2). These enzymes are activated by G-protein-coupled
                      receptors (GPCRs) through the interaction with the alpha
                      subunit of heterotrimeric G-proteins belonging to the Gq
                      family (Gαq), the Gβγ subunits released by the inhibitory
                      G-protein (Gi) and Ca2+ ions. Here we review current
                      structural insights on these important proteins, with a
                      particular focus on the most structurally characterized
                      isoform (PLC-β3) and the activation mechanism operated by
                      Gαq. We propose, following the lead of recent studies, that
                      a tight combination of experiments and molecular simulations
                      are instrumental in further enlightening the
                      structure/function understanding of PLC-βs. - See more at:
                      http://www.eurekaselect.com/116059/article#sthash.cojH1BB1.dpuf},
      cin          = {GRS / IAS-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)GRS-20100316 / I:(DE-Juel1)IAS-5-20120330},
      pnm          = {899 - ohne Topic (POF2-899)},
      pid          = {G:(DE-HGF)POF2-899},
      typ          = {PUB:(DE-HGF)16 / PUB:(DE-HGF)36},
      pubmed       = {pmid:24384033},
      UT           = {WOS:000329125100002},
      doi          = {10.2174/13892037113146660085},
      url          = {https://juser.fz-juelich.de/record/201303},
}