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| 001 | 201331 | ||
| 005 | 20240625095115.0 | ||
| 024 | 7 | _ | |a 10.1002/anie.201406910 |2 doi |
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| 100 | 1 | _ | |0 P:(DE-HGF)0 |a Arcella, Annalisa |b 0 |
| 245 | _ | _ | |a Structure and Dynamics of Oligonucleotides in the Gas Phase |
| 260 | _ | _ | |a Weinheim |b Wiley-VCH |c 2015 |
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| 520 | _ | _ | |a By combining ion-mobility mass spectrometry experiments with sub-millisecond classical and ab initio molecular dynamics we fully characterized, for the first time, the dynamic ensemble of a model nucleic acid in the gas phase under electrospray ionization conditions. The studied oligonucleotide unfolds upon vaporization, loses memory of the solution structure, and explores true gas-phase conformational space. Contrary to our original expectations, the oligonucleotide shows very rich dynamics in three different timescales (multi-picosecond, nanosecond, and sub-millisecond). The shorter timescale dynamics has a quantum mechanical nature and leads to changes in the covalent structure, whereas theother two are of classical origin. Overall, this study suggests that a re-evaluation on our view of the physics of nucleic acids upon vaporization is needed. |
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| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Orozco, Modesto |b 7 |e Corresponding Author |
| 773 | _ | _ | |0 PERI:(DE-600)2011836-3 |a 10.1002/anie.201406910 |g p. n/a - n/a |n 2 |p 467–471 |t Angewandte Chemie / International edition |v 54 |x 1433-7851 |y 2015 |
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