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@ARTICLE{Grison:201333,
      author       = {Grison, Alice and Zucchelli, Silvia and Urzì, Alice and
                      Zamparo, Ilaria and Lazarevic, Dejan and Pascarella,
                      Giovanni and Roncaglia, Paola and Giorgetti, Alejandro and
                      Garcia-Esparcia, Paula and Vlachouli, Christina and Simone,
                      Roberto and Persichetti, Francesca and Forrest, Alistair RR
                      and Hayashizaki, Yoshihide and Carloni, Paolo and Ferrer,
                      Isidro and Lodovichi, Claudia and Plessy, Charles and
                      Carninci, Piero and Gustincich, Stefano},
      title        = {{M}esencephalic dopaminergic neurons express a repertoire
                      of olfactory receptors and respond to odorant-like
                      molecules},
      journal      = {BMC genomics},
      volume       = {15},
      number       = {1},
      issn         = {1471-2164},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {FZJ-2015-03630},
      pages        = {729 -},
      year         = {2014},
      abstract     = {BackgroundThe mesencephalic dopaminergic (mDA) cell system
                      is composed of two major groups of projecting cells in the
                      Substantia Nigra (SN) (A9 neurons) and the Ventral Tegmental
                      Area (VTA) (A10 cells). Selective degeneration of A9 neurons
                      occurs in Parkinson’s disease (PD) while abnormal function
                      of A10 cells has been linked to schizophrenia, attention
                      deficit and addiction. The molecular basis that underlies
                      selective vulnerability of A9 and A10 neurons is presently
                      unknown.ResultsBy taking advantage of transgenic labeling,
                      laser capture microdissection coupled to nano Cap-Analysis
                      of Gene Expression (nanoCAGE) technology on isolated A9 and
                      A10 cells, we found that a subset of Olfactory Receptors
                      (OR)s is expressed in mDA neurons. Gene expression analysis
                      was integrated with the FANTOM5 Helicos CAGE sequencing
                      datasets, showing the presence of these ORs in selected
                      tissues and brain areas outside of the olfactory epithelium.
                      OR expression in the mesencephalon was validated by RT-PCR
                      and in situ hybridization. By screening 16 potential ligands
                      on 5 mDA ORs recombinantly expressed in an heterologous in
                      vitro system, we identified carvone enantiomers as agonists
                      at Olfr287 and able to evoke an intracellular Ca2+ increase
                      in solitary mDA neurons. ORs were found expressed in human
                      SN and down-regulated in PD post mortem
                      brains.ConclusionsOur study indicates that mDA neurons
                      express ORs and respond to odor-like molecules providing new
                      opportunities for pharmacological intervention in disease.},
      cin          = {INM-9 / IAS-5 / GRS},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-9-20140121 / I:(DE-Juel1)IAS-5-20120330 /
                      I:(DE-Juel1)GRS-20100316},
      pnm          = {899 - ohne Topic (POF2-899)},
      pid          = {G:(DE-HGF)POF2-899},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000341327800001},
      pubmed       = {pmid:25164183},
      doi          = {10.1186/1471-2164-15-729},
      url          = {https://juser.fz-juelich.de/record/201333},
}