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@ARTICLE{Tepest:201374,
      author       = {Tepest, Ralf and Schwarzbach, Christopher J. and Krug,
                      Barbara and Klosterkötter, Joachim and Ruhrmann, Stephan
                      and Vogeley, Kai},
      title        = {{M}orphometry of structural disconnectivity indicators in
                      subjects at risk and in age-matched patients with
                      schizophrenia},
      journal      = {European archives of psychiatry and clinical neuroscience},
      volume       = {263},
      number       = {1},
      issn         = {1433-8491},
      address      = {Darmstadt},
      publisher    = {Steinkopff},
      reportid     = {FZJ-2015-03669},
      pages        = {15 - 24},
      year         = {2013},
      abstract     = {Structural disconnectivity has been hypothesized as being
                      accountable for the pathophysiology of schizophrenia.
                      Morphometric variables suitable for the empirical study of
                      disconnectivity were studied aiming at the research question
                      whether empirical indicators for disconnectivity are already
                      informative in subjects at risk (SAR) and in young matched
                      patients diagnosed with schizophrenia (SZ). In MRI data of
                      subjects of the two diagnostic groups SZ and SAR, the size
                      of the corpus callosum (CC) as indicator for
                      interhemispherical long distance connections and the
                      gyrification index (GI) as indicator for cortico-cortical
                      connections were analyzed compared to a healthy controls
                      (HC). Each subgroup consists of 21 subjects matched for sex
                      and age. Measurements of the CC and GI were estimated in
                      manually performed tracing procedures. GI data revealed
                      significant differences between the diagnostic groups of
                      both SAR and SZ as compared to HC in the frontal and
                      parietal cortices. Measurements of total CC yielded no
                      significant differences between diagnostic groups. The
                      results are suggestive for impaired cortico-cortical
                      connections as indicated by gyrification changes in SZ and
                      also in SAR, whereas interhemispherical connectivity at the
                      same time appears to be unaffected.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333)},
      pid          = {G:(DE-HGF)POF2-333},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000314296300003},
      doi          = {10.1007/s00406-012-0343-6},
      url          = {https://juser.fz-juelich.de/record/201374},
}