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@ARTICLE{Schneider:201381,
      author       = {Schneider, Christian and Bucher, Franziska and Cursiefen,
                      Claus and Fink, Gereon R. and Heindl, Ludwig M. and Lehmann,
                      Helmar C.},
      title        = {{C}orneal confocal microscopy detects small fiber damage in
                      chronic inflammatory demyelinating polyneuropathy ({CIDP})},
      journal      = {Journal of the peripheral nervous system},
      volume       = {19},
      number       = {4},
      issn         = {1085-9489},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2015-03676},
      pages        = {322 - 327},
      year         = {2014},
      abstract     = {Chronic inflammatory demyelinating polyneuropathy (CIDP) is
                      an autoimmune-mediated peripheral neuropathy with multifocal
                      involvement. Reliable biomarkers for diagnosis, disease
                      progression, and treatment response remain to be developed.
                      We assessed the utility of corneal confocal microscopy (CCM)
                      as a diagnostic marker for CIDP in 16 patients. CCM
                      parameters including corneal nerve fiber density (NFD),
                      nerve fiber length, number of main nerve trunks, number of
                      nerve branches, nerve tortuosity, and dendritic cell density
                      (DCD) were compared to those from 15 healthy controls and
                      correlated with clinical and electrophysiological findings.
                      CIDP patients had a significantly lower corneal NFD compared
                      to healthy controls. The total nerve fiber length and the
                      number of nerve branches were significantly decreased,
                      whereas nerve tortuosity was increased in patients with
                      CIDP. There was no positive correlation between corneal NFD
                      and clinical or electrophysiological assessments. The
                      average DCD was not significantly different in CIDP patients
                      and controls. CCM measures suggest damage to small sensory
                      afferents in the cornea in CIDP patients. Further studies
                      are needed to compare different neuropathic conditions and
                      to explore longitudinal changes of CCM parameters.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333)},
      pid          = {G:(DE-HGF)POF2-333},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000349094100006},
      doi          = {10.1111/jns.12098},
      url          = {https://juser.fz-juelich.de/record/201381},
}