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@ARTICLE{Axer:20154,
      author       = {Axer, M. and Amunts, K. and Grässel, D. and Palm, C. and
                      Dammers, J. and Axer, H. and Pietrzyk, U. and Zilles, K.},
      title        = {{A} novel approach to the human connectome: ultra-high
                      resolution mapping of fiber tracts in the brain},
      journal      = {NeuroImage},
      volume       = {54},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {PreJuSER-20154},
      pages        = {1091 - 1101},
      year         = {2011},
      note         = {We would like to thank M. Cremer, F. Kocaer and H.
                      Mohlberg, Research Centre Julich, Germany, and U. Blohm and
                      U. Opfermann, University Dusseldorf, Germany, for excellent
                      technical assistance and preparation of the histological
                      sections. Our work was partly supported by the Initiative
                      and Network Fund of the Helmholtz Association within the
                      Helmholtz Alliance on Systems Biology ("Human Brain
                      Model").},
      abstract     = {Signal transmission between different brain regions
                      requires connecting fiber tracts, the structural basis of
                      the human connectome. In contrast to animal brains, where a
                      multitude of tract tracing methods can be used, magnetic
                      resonance (MR)-based diffusion imaging is presently the only
                      promising approach to study fiber tracts between specific
                      human brain regions. However, this procedure has various
                      inherent restrictions caused by its relatively low spatial
                      resolution. Here, we introduce 3D-polarized light imaging
                      (3D-PLI) to map the three-dimensional course of fiber tracts
                      in the human brain with a resolution at a submillimeter
                      scale based on a voxel size of 100 μm isotropic or less.
                      3D-PLI demonstrates nerve fibers by utilizing their
                      intrinsic birefringence of myelin sheaths surrounding axons.
                      This optical method enables the demonstration of 3D fiber
                      orientations in serial microtome sections of entire human
                      brains. Examples for the feasibility of this novel approach
                      are given here. 3D-PLI enables the study of brain regions of
                      intense fiber crossing in unprecedented detail, and provides
                      an independent evaluation of fiber tracts derived from
                      diffusion imaging data.},
      keywords     = {Birefringence / Brain: ultrastructure / Brain Mapping:
                      methods / Humans / Image Processing, Computer-Assisted:
                      methods / Imaging, Three-Dimensional: methods / Nerve
                      Fibers: ultrastructure / Neural Pathways: anatomy $\&$
                      histology / J (WoSType)},
      cin          = {INM-4 / INM-1 / INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-1-20090406 /
                      I:(DE-Juel1)INM-2-20090406},
      pnm          = {Neurowissenschaften (FUEK255) / 333 - Pathophysiological
                      Mechanisms of Neurological and Psychiatric Diseases
                      (POF2-333)},
      pid          = {G:(DE-Juel1)FUEK255 / G:(DE-HGF)POF2-333},
      shelfmark    = {Neurosciences / Neuroimaging / Radiology, Nuclear Medicine
                      $\&$ Medical Imaging},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20832489},
      UT           = {WOS:000285486000034},
      doi          = {10.1016/j.neuroimage.2010.08.075},
      url          = {https://juser.fz-juelich.de/record/20154},
}