Home > Publications database > A novel approach to the human connectome: ultra-high resolution mapping of fiber tracts in the brain > print

001     20154
005     20210129210742.0
024 7 _ |2 pmid
|a pmid:20832489
024 7 _ |2 DOI
|a 10.1016/j.neuroimage.2010.08.075
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037 _ _ |a PreJuSER-20154
041 _ _ |a eng
082 _ _ |a 610
084 _ _ |2 WoS
|a Neurosciences
084 _ _ |2 WoS
|a Neuroimaging
084 _ _ |2 WoS
|a Radiology, Nuclear Medicine & Medical Imaging
100 1 _ |a Axer, M.
|b 0
|u FZJ
|0 P:(DE-Juel1)VDB67318
245 _ _ |a A novel approach to the human connectome: ultra-high resolution mapping of fiber tracts in the brain
260 _ _ |a Orlando, Fla.
|b Academic Press
|c 2011
300 _ _ |a 1091 - 1101
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |a NeuroImage
|x 1053-8119
|0 4545
|y 2
|v 54
500 _ _ |3 POF3_Assignment on 2016-02-29
500 _ _ |a We would like to thank M. Cremer, F. Kocaer and H. Mohlberg, Research Centre Julich, Germany, and U. Blohm and U. Opfermann, University Dusseldorf, Germany, for excellent technical assistance and preparation of the histological sections. Our work was partly supported by the Initiative and Network Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology ("Human Brain Model").
520 _ _ |a Signal transmission between different brain regions requires connecting fiber tracts, the structural basis of the human connectome. In contrast to animal brains, where a multitude of tract tracing methods can be used, magnetic resonance (MR)-based diffusion imaging is presently the only promising approach to study fiber tracts between specific human brain regions. However, this procedure has various inherent restrictions caused by its relatively low spatial resolution. Here, we introduce 3D-polarized light imaging (3D-PLI) to map the three-dimensional course of fiber tracts in the human brain with a resolution at a submillimeter scale based on a voxel size of 100 μm isotropic or less. 3D-PLI demonstrates nerve fibers by utilizing their intrinsic birefringence of myelin sheaths surrounding axons. This optical method enables the demonstration of 3D fiber orientations in serial microtome sections of entire human brains. Examples for the feasibility of this novel approach are given here. 3D-PLI enables the study of brain regions of intense fiber crossing in unprecedented detail, and provides an independent evaluation of fiber tracts derived from diffusion imaging data.
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|c FUEK255
|a Neurowissenschaften (FUEK255)
536 _ _ |a 333 - Pathophysiological Mechanisms of Neurological and Psychiatric Diseases (POF2-333)
|0 G:(DE-HGF)POF2-333
|c POF2-333
|x 1
|f POF II
588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Birefringence
650 _ 2 |2 MeSH
|a Brain: ultrastructure
650 _ 2 |2 MeSH
|a Brain Mapping: methods
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Image Processing, Computer-Assisted: methods
650 _ 2 |2 MeSH
|a Imaging, Three-Dimensional: methods
650 _ 2 |2 MeSH
|a Nerve Fibers: ultrastructure
650 _ 2 |2 MeSH
|a Neural Pathways: anatomy & histology
650 _ 7 |a J
|2 WoSType
653 2 0 |2 Author
|a Connectome
653 2 0 |2 Author
|a Human brain
653 2 0 |2 Author
|a Method
653 2 0 |2 Author
|a Polarized light imaging
653 2 0 |2 Author
|a Tractography
653 2 0 |2 Author
|a Systems biology
700 1 _ |a Amunts, K.
|b 1
|u FZJ
|0 P:(DE-Juel1)131631
700 1 _ |a Grässel, D.
|b 2
|u FZJ
|0 P:(DE-Juel1)131642
700 1 _ |a Palm, C.
|b 3
|u FZJ
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700 1 _ |a Dammers, J.
|b 4
|u FZJ
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700 1 _ |a Axer, H.
|b 5
|u FZJ
|0 P:(DE-Juel1)VDB71120
700 1 _ |a Pietrzyk, U.
|b 6
|u FZJ
|0 P:(DE-Juel1)VDB2211
700 1 _ |a Zilles, K.
|b 7
|u FZJ
|0 P:(DE-Juel1)131714
773 _ _ |a 10.1016/j.neuroimage.2010.08.075
|g Vol. 54, p. 1091 - 1101
|p 1091 - 1101
|q 54<1091 - 1101
|0 PERI:(DE-600)1471418-8
|t NeuroImage
|v 54
|y 2011
|x 1053-8119
856 7 _ |u http://dx.doi.org/10.1016/j.neuroimage.2010.08.075
909 C O |o oai:juser.fz-juelich.de:20154
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|l Decoding the Human Brain
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