%0 Journal Article
%A Tran, Duy P.
%A Wolfrum, Bernhard
%A Stockmann, Regina
%A Pai, Jing-Hong
%A Pourhassan-Moghaddam, Mohammad
%A Offenhäusser, Andreas
%A Thierry, Benjamin
%T Complementary Metal Oxide Semiconductor Compatible Silicon Nanowires-on-a-Chip: Fabrication and Preclinical Validation for the Detection of a Cancer Prognostic Protein Marker in Serum
%J Analytical chemistry
%V 87
%N 3
%@ 1520-6882
%C Columbus, Ohio
%I American Chemical Society
%M FZJ-2015-04028
%P 1662 - 1668
%D 2015
%X An integrated translational biosensing technology based on arrays of silicon nanowire field-effect transistors (SiNW FETs) is described and has been preclinically validated for the ultrasensitive detection of the cancer biomarker ALCAM in serum. High-quality SiNW arrays have been rationally designed toward their implementation as molecular biosensors. The FET sensing platform has been fabricated using a complementary metal oxide semiconductor (CMOS)-compatible process. Reliable and reproducible electrical performance has been demonstrated via electrical characterization using a custom-designed portable readout device. Using this platform, the cancer prognostic marker ALCAM could be detected in serum with a detection limit of 15.5 pg/mL. Importantly, the detection could be completed in less than 30 min and span a wide dynamic detection range (∼105). The SiNW-on-a-chip biosensing technology paves the way to the translational clinical application of FET in the detection of cancer protein markers.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000349059000036
%$ pmid:25531273
%R 10.1021/ac503374j
%U https://juser.fz-juelich.de/record/201734