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000201734 1001_ $$0P:(DE-Juel1)136674$$aTran, Duy P.$$b0$$eCorresponding Author
000201734 245__ $$aComplementary Metal Oxide Semiconductor Compatible Silicon Nanowires-on-a-Chip: Fabrication and Preclinical Validation for the Detection of a Cancer Prognostic Protein Marker in Serum
000201734 260__ $$aColumbus, Ohio$$bAmerican Chemical Society$$c2015
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000201734 520__ $$aAn integrated translational biosensing technology based on arrays of silicon nanowire field-effect transistors (SiNW FETs) is described and has been preclinically validated for the ultrasensitive detection of the cancer biomarker ALCAM in serum. High-quality SiNW arrays have been rationally designed toward their implementation as molecular biosensors. The FET sensing platform has been fabricated using a complementary metal oxide semiconductor (CMOS)-compatible process. Reliable and reproducible electrical performance has been demonstrated via electrical characterization using a custom-designed portable readout device. Using this platform, the cancer prognostic marker ALCAM could be detected in serum with a detection limit of 15.5 pg/mL. Importantly, the detection could be completed in less than 30 min and span a wide dynamic detection range (∼105). The SiNW-on-a-chip biosensing technology paves the way to the translational clinical application of FET in the detection of cancer protein markers.
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000201734 7001_ $$0P:(DE-Juel1)128745$$aWolfrum, Bernhard$$b1
000201734 7001_ $$0P:(DE-Juel1)128733$$aStockmann, Regina$$b2
000201734 7001_ $$0P:(DE-HGF)0$$aPai, Jing-Hong$$b3
000201734 7001_ $$0P:(DE-HGF)0$$aPourhassan-Moghaddam, Mohammad$$b4
000201734 7001_ $$0P:(DE-Juel1)128713$$aOffenhäusser, Andreas$$b5$$eCorresponding Author
000201734 7001_ $$0P:(DE-HGF)0$$aThierry, Benjamin$$b6
000201734 773__ $$0PERI:(DE-600)1483443-1$$a10.1021/ac503374j$$gVol. 87, no. 3, p. 1662 - 1668$$n3$$p1662 - 1668$$tAnalytical chemistry$$v87$$x1520-6882$$y2015
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