TY  - JOUR
AU  - Tran, Duy P.
AU  - Wolfrum, Bernhard
AU  - Stockmann, Regina
AU  - Pai, Jing-Hong
AU  - Pourhassan-Moghaddam, Mohammad
AU  - Offenhäusser, Andreas
AU  - Thierry, Benjamin
TI  - Complementary Metal Oxide Semiconductor Compatible Silicon Nanowires-on-a-Chip: Fabrication and Preclinical Validation for the Detection of a Cancer Prognostic Protein Marker in Serum
JO  - Analytical chemistry
VL  - 87
IS  - 3
SN  - 1520-6882
CY  - Columbus, Ohio
PB  - American Chemical Society
M1  - FZJ-2015-04028
SP  - 1662 - 1668
PY  - 2015
AB  - An integrated translational biosensing technology based on arrays of silicon nanowire field-effect transistors (SiNW FETs) is described and has been preclinically validated for the ultrasensitive detection of the cancer biomarker ALCAM in serum. High-quality SiNW arrays have been rationally designed toward their implementation as molecular biosensors. The FET sensing platform has been fabricated using a complementary metal oxide semiconductor (CMOS)-compatible process. Reliable and reproducible electrical performance has been demonstrated via electrical characterization using a custom-designed portable readout device. Using this platform, the cancer prognostic marker ALCAM could be detected in serum with a detection limit of 15.5 pg/mL. Importantly, the detection could be completed in less than 30 min and span a wide dynamic detection range (∼105). The SiNW-on-a-chip biosensing technology paves the way to the translational clinical application of FET in the detection of cancer protein markers.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000349059000036
C6  - pmid:25531273
DO  - DOI:10.1021/ac503374j
UR  - https://juser.fz-juelich.de/record/201734
ER  -