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@ARTICLE{Tran:201734,
      author       = {Tran, Duy P. and Wolfrum, Bernhard and Stockmann, Regina
                      and Pai, Jing-Hong and Pourhassan-Moghaddam, Mohammad and
                      Offenhäusser, Andreas and Thierry, Benjamin},
      title        = {{C}omplementary {M}etal {O}xide {S}emiconductor
                      {C}ompatible {S}ilicon {N}anowires-on-a-{C}hip:
                      {F}abrication and {P}reclinical {V}alidation for the
                      {D}etection of a {C}ancer {P}rognostic {P}rotein {M}arker in
                      {S}erum},
      journal      = {Analytical chemistry},
      volume       = {87},
      number       = {3},
      issn         = {1520-6882},
      address      = {Columbus, Ohio},
      publisher    = {American Chemical Society},
      reportid     = {FZJ-2015-04028},
      pages        = {1662 - 1668},
      year         = {2015},
      abstract     = {An integrated translational biosensing technology based on
                      arrays of silicon nanowire field-effect transistors (SiNW
                      FETs) is described and has been preclinically validated for
                      the ultrasensitive detection of the cancer biomarker ALCAM
                      in serum. High-quality SiNW arrays have been rationally
                      designed toward their implementation as molecular
                      biosensors. The FET sensing platform has been fabricated
                      using a complementary metal oxide semiconductor
                      (CMOS)-compatible process. Reliable and reproducible
                      electrical performance has been demonstrated via electrical
                      characterization using a custom-designed portable readout
                      device. Using this platform, the cancer prognostic marker
                      ALCAM could be detected in serum with a detection limit of
                      15.5 pg/mL. Importantly, the detection could be completed in
                      less than 30 min and span a wide dynamic detection range
                      (∼105). The SiNW-on-a-chip biosensing technology paves the
                      way to the translational clinical application of FET in the
                      detection of cancer protein markers.},
      cin          = {PGI-8 / ICS-8 / JARA-FIT},
      ddc          = {540},
      cid          = {I:(DE-Juel1)PGI-8-20110106 / I:(DE-Juel1)ICS-8-20110106 /
                      $I:(DE-82)080009_20140620$},
      pnm          = {523 - Controlling Configuration-Based Phenomena (POF3-523)},
      pid          = {G:(DE-HGF)POF3-523},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000349059000036},
      pubmed       = {pmid:25531273},
      doi          = {10.1021/ac503374j},
      url          = {https://juser.fz-juelich.de/record/201734},
}