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@INPROCEEDINGS{Elmenhorst:201924,
      author       = {Elmenhorst, David. and Kroll, Tina. and Matusch, Andreas.
                      and Bauer, Andreas},
      title        = {{I}maging of adenosine receptors},
      journal      = {Purinergic signalling},
      volume       = {10},
      number       = {4},
      issn         = {1573-9538},
      address      = {Dordrecht},
      publisher    = {Springer Science + Business Media B.V.},
      reportid     = {FZJ-2015-04214},
      pages        = {744-744},
      year         = {2014},
      abstract     = {Over the last decades adenosine receptor ligands, agonists
                      as well as antagonists, have been developed. The
                      requirements for compounds suitable for non-invasivein vivo
                      imaging of adenosine receptors (radiopharmaceuticals,
                      radiotracers) with positron emission tomography (PET) are in
                      several aspects different from thosefor therapeutic drugs.
                      This difference will be elucidated for radiotracers involved
                      in human neurotransmission research.In humans theA1
                      adenosine receptor (A1AR) shows themost abundant
                      distribution and highest concentrations in brain cortical
                      and subcortical areas, whereas theA2Aadenosine receptor
                      (A2AAR) can be found in selected regions like striatum,
                      nucleus accumbens, olfactory tubercle. A2B adenosine
                      receptors (A2BAR) and A3 adenosinereceptors (A3ARs) are
                      expressed in low levels in the brain.Most of the imaging
                      probes therefore target the A1AR and A2AAR. The talk will
                      give an overview of currentlyused imaging probes and
                      applications. The neuroreceptor imaging technique has been
                      used for example to investigate physiological mechanisms of
                      the sleep wakeregulation or pathophysiological conditions
                      like cerebral ischemia, ethanol intoxication, epilepsy or
                      Alzheimer’s disease in humans and animal models.
                      Pharmacokineticanalysis of PET experiments allow
                      additionally to investigate drug action in the human brain,
                      like for example the impact of caffeine on A1AR
                      availability.},
      month         = {Jul},
      date          = {2014-07-23},
      organization  = {Purines 2014, Bonn (Germany), 23 Jul
                       2014 - 27 Jul 2014},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333)},
      pid          = {G:(DE-HGF)POF2-333},
      typ          = {PUB:(DE-HGF)8 / PUB:(DE-HGF)16},
      UT           = {WOS:000348578700228},
      url          = {https://juser.fz-juelich.de/record/201924},
}