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@ARTICLE{Sprooten:202019,
      author       = {Sprooten, Emma and McIntosh, Andrew M. and Lawrie, Stephen
                      M. and Hall, Jeremy and Sussmann, Jess E. and Dahmen,
                      Norbert and Konrad, Andreas and Bastin, Mark E. and
                      Winterer, Georg},
      title        = {{A}n investigation of a genomewide supported psychosis
                      variant in {ZNF}804{A} and white matter integrity in the
                      human brain},
      journal      = {Magnetic resonance imaging},
      volume       = {30},
      number       = {10},
      issn         = {0730-725X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2015-04308},
      pages        = {1373 - 1380},
      year         = {2012},
      abstract     = {ZNF804A, a genomewide supported susceptibility gene for
                      schizophrenia and bipolar disorder, has been associated with
                      task-independent functional connectivity between the left
                      and right dorsolateral prefrontal cortices. Several lines of
                      evidence have converged on the hypothesis that this effect
                      may be mediated by structural connectivity. We tested this
                      hypothesis using diffusion tensor magnetic resonance imaging
                      in three samples: one German sample of 50 healthy
                      individuals, one Scottish sample of 83 healthy individuals
                      and one Scottish sample of 84 unaffected relatives of
                      bipolar patients. Voxel-based analysis and tract-based
                      spatial statistics did not detect any fractional anisotropy
                      (FA) differences between minor allele carriers and
                      individuals homozygous for the major allele at rs1344706.
                      Similarly, region-of-interest analyses and quantitative
                      tractography of the genu of the corpus callosum revealed no
                      significant FA differences between the genotype groups.
                      Examination of effect sizes and confidence intervals
                      indicated that this negative finding is very unlikely to be
                      due to a lack of statistical power. In summary, despite
                      using various analysis techniques in three different
                      samples, our results were strikingly and consistently
                      negative. These data therefore suggest that it is unlikely
                      that the effects of genetic variation at rs1344706 on
                      functional connectivity are mediated by structural integrity
                      differences in large, long-range white matter fiber
                      connections.},
      cin          = {INM-3 / INM-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333)},
      pid          = {G:(DE-HGF)POF2-333},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000311261000002},
      pubmed       = {pmid:22840435},
      doi          = {10.1016/j.mri.2012.05.013},
      url          = {https://juser.fz-juelich.de/record/202019},
}