000202023 001__ 202023
000202023 005__ 20210129220008.0
000202023 0247_ $$2doi$$a10.1073/pnas.1118051109
000202023 0247_ $$2ISSN$$a0027-8424
000202023 0247_ $$2ISSN$$a1091-6490
000202023 0247_ $$2WOS$$aWOS:000303246100073
000202023 0247_ $$2altmetric$$aaltmetric:668785
000202023 0247_ $$2pmid$$apmid:22451930
000202023 037__ $$aFZJ-2015-04312
000202023 082__ $$a000
000202023 1001_ $$0P:(DE-HGF)0$$aQuednow, B. B.$$b0$$eCorresponding Author
000202023 245__ $$aSchizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating
000202023 260__ $$aWashington, DC$$bNational Acad. of Sciences$$c2012
000202023 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1435665746_745
000202023 3367_ $$2DataCite$$aOutput Types/Journal article
000202023 3367_ $$00$$2EndNote$$aJournal Article
000202023 3367_ $$2BibTeX$$aARTICLE
000202023 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000202023 3367_ $$2DRIVER$$aarticle
000202023 520__ $$aSeveral polymorphisms of the transcription factor 4 (TCF4) have been shown to increase the risk for schizophrenia, particularly TCF4 rs9960767. This polymorphism is associated with impaired sensorimotor gating measured by prepulse inhibition—an established endophenotype of schizophrenia. We therefore investigated whether TCF4 polymorphisms also affect another proposed endophenotype of schizophrenia, namely sensory gating assessed by P50 suppression of the auditory evoked potential. Although sensorimotor gating and sensory gating are not identical, recent data suggest that they share genetic fundamentals. In a multicenter study at six academic institutions throughout Germany, we applied an auditory P50 suppression paradigm to 1,821 subjects (1,023 never-smokers, 798 smokers) randomly selected from the general population. Samples were genotyped for 21 TCF4 polymorphisms. Given that smoking is highly prevalent in schizophrenia and affects sensory gating, we also assessed smoking behavior, cotinine plasma concentrations, exhaled carbon monoxide, and the Fagerström Test (FTND). P50 suppression was significantly decreased in carriers of schizophrenia risk alleles of the TCF4 polymorphisms rs9960767, rs10401120rs, rs17597926, and 17512836 (P < 0.0002–0.00005). These gene effects were modulated by smoking behavior as indicated by significant interactions of TCF4 genotype and smoking status; heavy smokers (FTND score ≥4) showed stronger gene effects on P50 suppression than light smokers and never-smokers. Our finding suggests that sensory gating is modulated by an interaction of TCF4 genotype with smoking, and both factors may play a role in early information processing deficits also in schizophrenia. Consequently, considering smoking behavior may facilitate the search for genetic risk factors for schizophrenia. 
000202023 536__ $$0G:(DE-HGF)POF2-333$$a333 - Pathophysiological Mechanisms of Neurological and Psychiatric Diseases (POF2-333)$$cPOF2-333$$fPOF II$$x0
000202023 588__ $$aDataset connected to CrossRef, juser.fz-juelich.de
000202023 7001_ $$0P:(DE-HGF)0$$aBrinkmeyer, J.$$b1
000202023 7001_ $$0P:(DE-HGF)0$$aMobascher, A.$$b2
000202023 7001_ $$0P:(DE-HGF)0$$aNothnagel, M.$$b3
000202023 7001_ $$0P:(DE-HGF)0$$aMusso, F.$$b4
000202023 7001_ $$0P:(DE-HGF)0$$aGrunder, G.$$b5
000202023 7001_ $$0P:(DE-HGF)0$$aSavary, N.$$b6
000202023 7001_ $$0P:(DE-HGF)0$$aPetrovsky, N.$$b7
000202023 7001_ $$0P:(DE-HGF)0$$aFrommann, I.$$b8
000202023 7001_ $$0P:(DE-HGF)0$$aLennertz, L.$$b9
000202023 7001_ $$0P:(DE-HGF)0$$aSpreckelmeyer, K. N.$$b10
000202023 7001_ $$0P:(DE-HGF)0$$aWienker, T. F.$$b11
000202023 7001_ $$0P:(DE-HGF)0$$aDahmen, N.$$b12
000202023 7001_ $$0P:(DE-HGF)0$$aThuerauf, N.$$b13
000202023 7001_ $$0P:(DE-HGF)0$$aClepce, M.$$b14
000202023 7001_ $$0P:(DE-HGF)0$$aKiefer, F.$$b15
000202023 7001_ $$0P:(DE-HGF)0$$aMajic, T.$$b16
000202023 7001_ $$0P:(DE-HGF)0$$aMossner, R.$$b17
000202023 7001_ $$0P:(DE-HGF)0$$aMaier, W.$$b18
000202023 7001_ $$0P:(DE-HGF)0$$aGallinat, J.$$b19
000202023 7001_ $$0P:(DE-HGF)0$$aDiaz-Lacava, A.$$b20
000202023 7001_ $$0P:(DE-HGF)0$$aToliat, M. R.$$b21
000202023 7001_ $$0P:(DE-HGF)0$$aThiele, H.$$b22
000202023 7001_ $$0P:(DE-HGF)0$$aNurnberg, P.$$b23
000202023 7001_ $$0P:(DE-HGF)0$$aWagner, M.$$b24
000202023 7001_ $$0P:(DE-HGF)0$$aWinterer, G.$$b25
000202023 773__ $$0PERI:(DE-600)1461794-8$$a10.1073/pnas.1118051109$$gVol. 109, no. 16, p. 6271 - 6276$$n16$$p6271 - 6276$$tProceedings of the National Academy of Sciences of the United States of America$$v109$$x1091-6490$$y2012
000202023 909CO $$ooai:juser.fz-juelich.de:202023$$pVDB
000202023 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-HGF)0$$aForschungszentrum Jülich GmbH$$b1$$kFZJ
000202023 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-HGF)0$$aForschungszentrum Jülich GmbH$$b2$$kFZJ
000202023 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)128533$$aExternal Institute$$b18$$kExtern
000202023 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)164435$$aExternal Institute$$b24$$kExtern
000202023 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-HGF)0$$aForschungszentrum Jülich GmbH$$b25$$kFZJ
000202023 9132_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x0
000202023 9131_ $$0G:(DE-HGF)POF2-333$$1G:(DE-HGF)POF2-330$$2G:(DE-HGF)POF2-300$$3G:(DE-HGF)POF2$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lFunktion und Dysfunktion des Nervensystems$$vPathophysiological Mechanisms of Neurological and Psychiatric Diseases$$x0
000202023 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR
000202023 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000202023 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000202023 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000202023 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000202023 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000202023 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000202023 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000202023 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000202023 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record
000202023 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000202023 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences
000202023 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5
000202023 920__ $$lyes
000202023 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x0
000202023 9201_ $$0I:(DE-Juel1)INM-4-20090406$$kINM-4$$lPhysik der Medizinischen Bildgebung$$x1
000202023 980__ $$ajournal
000202023 980__ $$aVDB
000202023 980__ $$aI:(DE-Juel1)INM-3-20090406
000202023 980__ $$aI:(DE-Juel1)INM-4-20090406
000202023 980__ $$aUNRESTRICTED
000202023 981__ $$aI:(DE-Juel1)INM-4-20090406