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@ARTICLE{Li:202044,
      author       = {Li, Pinggui and Greben, Kyrylo and Wördenweber, Roger and
                      Simon, Ulrich and Offenhäusser, Andreas and Mayer, Dirk},
      title        = {{T}uning neuron adhesion and neurite guiding using
                      functionalized {A}u{NP}s and backfill chemistry},
      journal      = {RSC Advances},
      volume       = {5},
      number       = {49},
      issn         = {2046-2069},
      address      = {London},
      publisher    = {RSC Publishing},
      reportid     = {FZJ-2015-04333},
      pages        = {39252 - 39262},
      year         = {2015},
      abstract     = {The adhesion of neurons depends on the interplay between
                      attractive as well as repellant cues in the cell membrane
                      and adhesion ligands in their cellular environment. In this
                      study, an easy and versatile strategy is presented to
                      control the density of cell binding sites embedded in a cell
                      repulsive environment attached to a solid surface. Gold
                      nanoparticles modified by positively charged aminoalkyl
                      thiols are used as artificial neuron adhesion ligands. The
                      density of the nanoparticles and their environment is varied
                      by applying either no backfill, poly(ethylene
                      glycol)-silane, or octyltrichlorosilane backfill. By this
                      means the chemical composition of both cell attractive
                      adhesion ligands and surrounding repellant cues is tuned on
                      the nanometer scale. Primary rat cortical neurons are
                      cultured on these particle modified surfaces. The viability
                      and neuritogenesis of neurons is investigated as a function
                      of particle density and background composition. A strong
                      dependence of neuron viability on both averaged particle
                      density and backfill composition is found in particular for
                      intermediate particle packing. At high particle densities,
                      the kind of backfill does not affect the cell viability but
                      influences the development of neurites. This knowledge is
                      used to enhance the guiding efficiency of neuron adhesion to
                      more than $90\%$ on nanopatterned surfaces.},
      cin          = {ICS-8 / PGI-8 / JARA-FIT},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-8-20110106 / I:(DE-Juel1)PGI-8-20110106 /
                      $I:(DE-82)080009_20140620$},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000354201500053},
      doi          = {10.1039/C5RA06901G},
      url          = {https://juser.fz-juelich.de/record/202044},
}