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000202095 1001_ $$0P:(DE-HGF)0$$aLuers, Lars$$b0
000202095 245__ $$aKinetics of Advanced Glycation End Products Formation on Bovine Serum Albumin with Various Reducing Sugars and Dicarbonyl Compounds in Equimolar Ratios
000202095 260__ $$aLarchmont, NY$$bLiebert$$c2012
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000202095 520__ $$aReducing sugars and reactive dicarbonyl compounds play a major role in glycation of proteins in vivo. Glycation of proteins is the first step in of a nonenzymatic reaction, resulting in advanced glycation end products (AGEs). AGEs can inactivate proteins or modify their biological activities. Therefore, it is important to understand the mechanism of AGE formation. Here, we systematically analyzed the kinetics of AGE formation in vitro by fluorescence and absorption measurements utilizing a microplate reader system and bovine serum albumin (BSA) as a model protein. Comparing different concentrations of BSA, we applied various reducing sugars and reactive dicarbonyl compounds as AGE-inducing agents at different concentrations. In summary, this experimental setup enabled us to measure the kinetics of AGE formation in an efficient and defined way.
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000202095 650_7 $$2NLM Chemicals$$aCarbohydrates
000202095 650_7 $$2NLM Chemicals$$aGlycosylation End Products, Advanced
000202095 650_7 $$2NLM Chemicals$$aSerum Albumin, Bovine
000202095 650_7 $$030237-26-4$$2NLM Chemicals$$aFructose
000202095 650_7 $$0681HV46001$$2NLM Chemicals$$aRibose
000202095 650_7 $$094ZLA3W45F$$2NLM Chemicals$$aArginine
000202095 650_7 $$0IY9XDZ35W2$$2NLM Chemicals$$aGlucose
000202095 7001_ $$0P:(DE-HGF)0$$aRysiewski, K.$$b1
000202095 7001_ $$0P:(DE-HGF)0$$aDumpitak, Christian$$b2
000202095 7001_ $$0P:(DE-Juel1)131992$$aBirkmann, Eva$$b3$$eCorresponding Author
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