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@ARTICLE{Luers:202095,
      author       = {Luers, Lars and Rysiewski, K. and Dumpitak, Christian and
                      Birkmann, Eva},
      title        = {{K}inetics of {A}dvanced {G}lycation {E}nd {P}roducts
                      {F}ormation on {B}ovine {S}erum {A}lbumin with {V}arious
                      {R}educing {S}ugars and {D}icarbonyl {C}ompounds in
                      {E}quimolar {R}atios},
      journal      = {Rejuvenation research},
      volume       = {15},
      number       = {2},
      issn         = {1094-5458},
      address      = {Larchmont, NY},
      publisher    = {Liebert},
      reportid     = {FZJ-2015-04384},
      pages        = {201 - 205},
      year         = {2012},
      abstract     = {Reducing sugars and reactive dicarbonyl compounds play a
                      major role in glycation of proteins in vivo. Glycation of
                      proteins is the first step in of a nonenzymatic reaction,
                      resulting in advanced glycation end products (AGEs). AGEs
                      can inactivate proteins or modify their biological
                      activities. Therefore, it is important to understand the
                      mechanism of AGE formation. Here, we systematically analyzed
                      the kinetics of AGE formation in vitro by fluorescence and
                      absorption measurements utilizing a microplate reader system
                      and bovine serum albumin (BSA) as a model protein. Comparing
                      different concentrations of BSA, we applied various reducing
                      sugars and reactive dicarbonyl compounds as AGE-inducing
                      agents at different concentrations. In summary, this
                      experimental setup enabled us to measure the kinetics of AGE
                      formation in an efficient and defined way.},
      keywords     = {Carbohydrates (NLM Chemicals) / Glycosylation End Products,
                      Advanced (NLM Chemicals) / Serum Albumin, Bovine (NLM
                      Chemicals) / Fructose (NLM Chemicals) / Ribose (NLM
                      Chemicals) / Arginine (NLM Chemicals) / Glucose (NLM
                      Chemicals)},
      cin          = {ICS-6},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {452 - Structural Biology (POF2-452)},
      pid          = {G:(DE-HGF)POF2-452},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22533432},
      UT           = {WOS:000303383600021},
      doi          = {10.1089/rej.2011.1284},
      url          = {https://juser.fz-juelich.de/record/202095},
}