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000202133 1001_ $$0P:(DE-Juel1)131968$$aIshchenko, A.$$b0
000202133 245__ $$aGround state structure of D75N mutant of sensory rhodopsin II in complex with its cognate transducer
000202133 260__ $$aNew York, NY [u.a.]$$bElsevier$$c2013
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000202133 520__ $$aThe complex of sensory rhodopsin II (NpSRII) with its cognate transducer (NpHtrII) mediates negative phototaxis in halobacteria Natronomonas pharaonis. Upon light activation NpSRII triggers, by means of NpHtrII, a signal transduction chain homologous to the two component system in eubacterial chemotaxis. Here we report on the crystal structure of the ground state of the mutant NpSRII-D75N/NpHtrII complex in the space group I212121. Mutations of this aspartic acid in light-driven proton pumps dramatically modify or/and inhibit protein functions. However, in vivo studies show that the similar D75N mutation retains functionality of the NpSRII/NpHtrII complex. The structure provides the molecular basis for the explanation of the unexpected observation that the wild and the mutant complexes display identical physiological response on light excitation.
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000202133 7001_ $$0P:(DE-HGF)0$$aRound, E.$$b1
000202133 7001_ $$0P:(DE-Juel1)144613$$aBorshchevskiy, V.$$b2
000202133 7001_ $$0P:(DE-HGF)0$$aGrudinin, S.$$b3
000202133 7001_ $$0P:(DE-Juel1)165798$$aGushchin, I.$$b4$$ufzj
000202133 7001_ $$0P:(DE-HGF)0$$aKlare, J. P.$$b5
000202133 7001_ $$0P:(DE-Juel1)131949$$aBalandin, T.$$b6$$ufzj
000202133 7001_ $$0P:(DE-HGF)0$$aRemeeva, A.$$b7
000202133 7001_ $$0P:(DE-HGF)0$$aEngelhard, M.$$b8
000202133 7001_ $$0P:(DE-Juel1)131957$$aBüldt, G.$$b9$$ufzj
000202133 7001_ $$0P:(DE-Juel1)131964$$aGordeliy, V.$$b10$$eCorresponding Author$$ufzj
000202133 773__ $$0PERI:(DE-600)1482691-4$$a10.1016/j.jphotobiol.2013.03.008$$gVol. 123, p. 55 - 58$$p55 - 58$$tJournal of photochemistry and photobiology / B$$v123$$x1011-1344$$y2013
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