Home > Publications database > Ground state structure of D75N mutant of sensory rhodopsin II in complex with its cognate transducer > print

001     202133
005     20240610115647.0
024 7 _ |a 10.1016/j.jphotobiol.2013.03.008
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024 7 _ |a 1011-1344
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024 7 _ |a 1873-2682
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082 _ _ |a 570
100 1 _ |a Ishchenko, A.
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245 _ _ |a Ground state structure of D75N mutant of sensory rhodopsin II in complex with its cognate transducer
260 _ _ |a New York, NY [u.a.]
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336 7 _ |a Journal Article
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520 _ _ |a The complex of sensory rhodopsin II (NpSRII) with its cognate transducer (NpHtrII) mediates negative phototaxis in halobacteria Natronomonas pharaonis. Upon light activation NpSRII triggers, by means of NpHtrII, a signal transduction chain homologous to the two component system in eubacterial chemotaxis. Here we report on the crystal structure of the ground state of the mutant NpSRII-D75N/NpHtrII complex in the space group I212121. Mutations of this aspartic acid in light-driven proton pumps dramatically modify or/and inhibit protein functions. However, in vivo studies show that the similar D75N mutation retains functionality of the NpSRII/NpHtrII complex. The structure provides the molecular basis for the explanation of the unexpected observation that the wild and the mutant complexes display identical physiological response on light excitation.
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700 1 _ |a Round, E.
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700 1 _ |a Borshchevskiy, V.
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700 1 _ |a Grudinin, S.
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700 1 _ |a Gushchin, I.
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700 1 _ |a Klare, J. P.
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700 1 _ |a Balandin, T.
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700 1 _ |a Remeeva, A.
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700 1 _ |a Engelhard, M.
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700 1 _ |a Büldt, G.
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700 1 _ |a Gordeliy, V.
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773 _ _ |a 10.1016/j.jphotobiol.2013.03.008
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