%0 Journal Article
%A Stencel-Baerenwald, Jennifer E
%A Reiss, Kerstin
%A Reiter, Dirk M
%A Stehle, Thilo
%A Dermody, Terence S
%T The sweet spot: defining virus-sialic acid interactions
%J Nature reviews / Microbiology
%V 12
%N 11
%@ 1740-1534
%C Basingstoke
%I Nature Publ. Group
%M FZJ-2015-04430
%P 739 - 749
%D 2014
%X Viral infections are initiated by attachment of the virus to host cell surface receptors, including sialic acid-containing glycans. It is now possible to rapidly identify specific glycan receptors using glycan array screening, to define atomic-level structures of virus-glycan complexes and to alter the glycan-binding site to determine the function of glycan engagement in viral disease. This Review highlights general principles of virus-glycan interactions and provides specific examples of sialic acid binding by viruses with stalk-like attachment proteins, including influenza virus, reovirus, adenovirus and rotavirus. Understanding virus-glycan interactions is essential to combating viral infections and designing improved viral vectors for therapeutic applications.
%K Polysaccharides (NLM Chemicals)
%K Receptors, Cell Surface (NLM Chemicals)
%K Receptors, Virus (NLM Chemicals)
%K N-Acetylneuraminic Acid (NLM Chemicals)
%F PUB:(DE-HGF)16 ; PUB:(DE-HGF)36
%9 Journal ArticleReview
%$ pmid:25263223
%U <Go to ISI:>//WOS:000343916900008
%R 10.1038/nrmicro3346
%U https://juser.fz-juelich.de/record/202141