TY  - JOUR
AU  - Stencel-Baerenwald, Jennifer E
AU  - Reiss, Kerstin
AU  - Reiter, Dirk M
AU  - Stehle, Thilo
AU  - Dermody, Terence S
TI  - The sweet spot: defining virus-sialic acid interactions
JO  - Nature reviews / Microbiology
VL  - 12
IS  - 11
SN  - 1740-1534
CY  - Basingstoke
PB  - Nature Publ. Group
M1  - FZJ-2015-04430
SP  - 739 - 749
PY  - 2014
AB  - Viral infections are initiated by attachment of the virus to host cell surface receptors, including sialic acid-containing glycans. It is now possible to rapidly identify specific glycan receptors using glycan array screening, to define atomic-level structures of virus-glycan complexes and to alter the glycan-binding site to determine the function of glycan engagement in viral disease. This Review highlights general principles of virus-glycan interactions and provides specific examples of sialic acid binding by viruses with stalk-like attachment proteins, including influenza virus, reovirus, adenovirus and rotavirus. Understanding virus-glycan interactions is essential to combating viral infections and designing improved viral vectors for therapeutic applications.
KW  - Polysaccharides (NLM Chemicals)
KW  - Receptors, Cell Surface (NLM Chemicals)
KW  - Receptors, Virus (NLM Chemicals)
KW  - N-Acetylneuraminic Acid (NLM Chemicals)
LB  - PUB:(DE-HGF)16 ; PUB:(DE-HGF)36
C6  - pmid:25263223
UR  - <Go to ISI:>//WOS:000343916900008
DO  - DOI:10.1038/nrmicro3346
UR  - https://juser.fz-juelich.de/record/202141
ER  -