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@ARTICLE{Gushchin:202160,
      author       = {Gushchin, Ivan and Shevchenko, Vitaly and Polovinkin, V.
                      and Kovalev, Kirill and Alekseev, Alexey and Round, E. and
                      Borshchevskiy, Valentin and Balandin, Taras and Popov, A.
                      and Gensch, Thomas and Fahlke, Christoph and Bamann, C. and
                      Willbold, Dieter and Büldt, Georg and Bamberg, E. and
                      Gordeliy, Valentin},
      title        = {{C}rystal structure of a light-driven sodium pump},
      journal      = {Nature structural $\&$ molecular biology},
      volume       = {22},
      number       = {5},
      issn         = {1545-9993},
      address      = {New York, NY},
      publisher    = {Nature America},
      reportid     = {FZJ-2015-04449},
      pages        = {390-395},
      year         = {2015},
      abstract     = {Recently, the first known light-driven sodium pumps, from
                      the microbial rhodopsin family, were discovered. We have
                      solved the structure of one of them, Krokinobacter eikastus
                      ​rhodopsin 2 (​KR2), in the monomeric blue state and in
                      two pentameric red states, at resolutions of 1.45 Å and 2.2
                      and 2.8 Å, respectively. The structures reveal the
                      ion-translocation pathway and show that the sodium ion is
                      bound outside the protein at the oligomerization interface,
                      that the ion-release cavity is capped by a unique N-terminal
                      α-helix and that the ion-uptake cavity is unexpectedly
                      large and open to the surface. Obstruction of the cavity
                      with the mutation G263F imparts ​KR2 with the ability to
                      pump potassium. These results pave the way for the
                      understanding and rational design of cation pumps with new
                      specific properties valuable for optogenetics.},
      cin          = {ICS-5 / ICS-6 / ICS-4},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-5-20110106 / I:(DE-Juel1)ICS-6-20110106 /
                      I:(DE-Juel1)ICS-4-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000354094700012},
      pubmed       = {pmid:25849142},
      doi          = {10.1038/nsmb.3002},
      url          = {https://juser.fz-juelich.de/record/202160},
}