%0 Journal Article
%A Feng, Lingyan
%A Lyu, Zhaozi
%A Offenhäusser, Andreas
%A Mayer, Dirk
%T Multi-Level Logic Gate Operation Based on Amplified Aptasensor Performance
%J Angewandte Chemie / International edition
%V 54
%N 26
%@ 1433-7851
%C Weinheim
%I Wiley-VCH
%M FZJ-2015-04586
%P 7693 - 7697
%D 2015
%X Conventional electronic circuits can perform multi-level logic operations; however, this capability is rarely realized by biological logic gates. In addition, the question of how to close the gap between biomolecular computation and silicon-based electrical circuitry is still a key issue in the bioelectronics field. Here we explore a novel split aptamer-based multi-level logic gate built from INHIBIT and AND gates that performs a net XOR analysis, with electrochemical signal as output. Based on the aptamer–target interaction and a novel concept of electrochemical rectification, a relayed charge transfer occurs upon target binding between aptamer-linked redox probes and solution-phase probes, which amplifies the sensor signal and facilitates a straightforward and reliable diagnosis. This work reveals a new route for the design of bioelectronic logic circuits that can realize multi-level logic operation, which has the potential to simplify an otherwise complex diagnosis to a “yes” or “no” decision.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000356390900045
%$ pmid:25959438
%R 10.1002/anie.201502315
%U https://juser.fz-juelich.de/record/202322