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000202322 1001_ $$0P:(DE-Juel1)157885$$aFeng, Lingyan$$b0
000202322 245__ $$aMulti-Level Logic Gate Operation Based on Amplified Aptasensor Performance
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000202322 520__ $$aConventional electronic circuits can perform multi-level logic operations; however, this capability is rarely realized by biological logic gates. In addition, the question of how to close the gap between biomolecular computation and silicon-based electrical circuitry is still a key issue in the bioelectronics field. Here we explore a novel split aptamer-based multi-level logic gate built from INHIBIT and AND gates that performs a net XOR analysis, with electrochemical signal as output. Based on the aptamer–target interaction and a novel concept of electrochemical rectification, a relayed charge transfer occurs upon target binding between aptamer-linked redox probes and solution-phase probes, which amplifies the sensor signal and facilitates a straightforward and reliable diagnosis. This work reveals a new route for the design of bioelectronic logic circuits that can realize multi-level logic operation, which has the potential to simplify an otherwise complex diagnosis to a “yes” or “no” decision.
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000202322 7001_ $$0P:(DE-Juel1)162320$$aLyu, Zhaozi$$b1
000202322 7001_ $$0P:(DE-Juel1)128713$$aOffenhäusser, Andreas$$b2
000202322 7001_ $$0P:(DE-Juel1)128707$$aMayer, Dirk$$b3$$eCorresponding Author
000202322 773__ $$0PERI:(DE-600)2011836-3$$a10.1002/anie.201502315$$gVol. 54, no. 26, p. 7693 - 7697$$n26$$p7693 - 7697$$tAngewandte Chemie / International edition$$v54$$x1433-7851$$y2015
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