TY  - JOUR
AU  - Feng, Lingyan
AU  - Lyu, Zhaozi
AU  - Offenhäusser, Andreas
AU  - Mayer, Dirk
TI  - Multi-Level Logic Gate Operation Based on Amplified Aptasensor Performance
JO  - Angewandte Chemie / International edition
VL  - 54
IS  - 26
SN  - 1433-7851
CY  - Weinheim
PB  - Wiley-VCH
M1  - FZJ-2015-04586
SP  - 7693 - 7697
PY  - 2015
AB  - Conventional electronic circuits can perform multi-level logic operations; however, this capability is rarely realized by biological logic gates. In addition, the question of how to close the gap between biomolecular computation and silicon-based electrical circuitry is still a key issue in the bioelectronics field. Here we explore a novel split aptamer-based multi-level logic gate built from INHIBIT and AND gates that performs a net XOR analysis, with electrochemical signal as output. Based on the aptamer–target interaction and a novel concept of electrochemical rectification, a relayed charge transfer occurs upon target binding between aptamer-linked redox probes and solution-phase probes, which amplifies the sensor signal and facilitates a straightforward and reliable diagnosis. This work reveals a new route for the design of bioelectronic logic circuits that can realize multi-level logic operation, which has the potential to simplify an otherwise complex diagnosis to a “yes” or “no” decision.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000356390900045
C6  - pmid:25959438
DO  - DOI:10.1002/anie.201502315
UR  - https://juser.fz-juelich.de/record/202322
ER  -